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Abnormal Glucose Metabolism in Hispanic Parents of Children with Acanthosis Nigricans

By Ximena Urrutia-Rojas, Walter McConathy, Benjamin Willis, John Menchaca, Mary Luna-Hollen, Khiya Marshall, Andras Lacko and Craig Spellman


Objective. Assess the prevalence of abnormal glucose metabolism among Hispanic parents of children with acanthosis nigricans (AN). Methods. Hispanic families (n = 258) were evaluated for metabolic and anthropometric parameters including fasting glucose levels and AN status. Results. Mothers with AN+ children had IFG (17.3%) and 4% had glucose levels ≥126 mg/dL (P = 0.028) compared to 7.1% and 1.8% of mothers with AN− children, respectively. Mothers of AN+ children also had greater odds of having impaired fasting glucose levels (OR: 3.917, 95% CI: 1.475–10.404; P < 0.004) but this was not the case for fathers (OR: 1.125, 95% CI: 0.489–2.586; P = 0.781). Mothers of AN+ children were also more likely to be AN+ (OR: 5.76, 95% CI: 2.98–11.13, P < 0.001). Screening discovered glucose levels >126 mg/dL in 9% of fathers with AN+ children. Conclusions. Hispanic mothers of AN+ children are at higher risk of carbohydrate metabolism abnormalities. AN in children can be a marker for prevention and delay programs aimed at identifying adults at risk for diabetes

Topics: Research Article
Publisher: International Scholarly Research Network
OAI identifier:
Provided by: PubMed Central

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  1. (2002). Acanthosis nigricans with endometrial carcinoma: case report and review of the literature,”
  2. (1998). Acanthosis nigricans,”
  3. (2004). American Diabetes Association;
  4. (2000). Association, “Type 2 diabetes in children and adolescents,”
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  6. (1999). Epidemiology of diabetes interventions and complications (EDIC): design, implementation, and preliminary results of a long-term follow-up of the diabetes control and complications trial cohort,” Diabetes Care,
  7. (1987). Familial acanthosis nigricans. A longitudinal study,”
  8. (1994). Familial aggregation of cardiovascular diseases
  9. (2004). Insulin resistance syndrome in children,”
  10. (2007). N a t h a n ,M .B .D a v i d s o n ,R .A .D e F r o n z oe ta l . , “Impaired fasting glucose and impaired glucose tolerance: implications for care,” Diabetes Care,
  11. (2007). Nongenomic transgenerational inheritance of disease risk,”
  12. (2006). Obesity in childhood and cardiovascular risk,”
  13. (2004). Prevalence of acanthosis nigricans
  14. (2002). Prevalence of impaired glucose tolerance among children and adolescents with marked obesity,”
  15. R a d e r ,“ E ffect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus,”
  16. (2002). S t o d d a r t ,K .S .B l e v i n s
  17. (1989). S t u a r t ,C .J .P a t e ,a n dE .J .P e t e r s ,“ P r e v a l e n c eo f acanthosis nigricans in an unselected population,”
  18. (1976). Some lessons in cardiovascular epidemiology from Framingham,”
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  20. (2001). The autosomal dominant trait of obesity, acanthosis nigricans, hypertension,
  21. (2008). The UKPDS and its global impact,”
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  23. (2004). X.Urrutia-Rojas,J.Menchaca,W.Wadleyetal.,“Cardiovascular risk factors in Mexican-American children at risk for type 2 diabetes mellitus (T2DM),”

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