A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

Revenu, Céline; Ubelmann, Florent; Hurbain, Ilse; El-Marjou, Fatima; Dingli, Florent; Loew, Damarys; Delacour, Delphine; Gilet, Jules; Brot-Laroche, Edith; Rivero, Francisco; Louvard, Daniel; Robine, Sylvie

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

By Céline Revenu, Florent Ubelmann, Ilse Hurbain, Fatima El-Marjou, Florent Dingli, Damarys Loew, Delphine Delacour, Jules Gilet, Edith Brot-Laroche, Francisco Rivero, Daniel Louvard and Sylvie Robine

Abstract

The bundled architecture of actin filaments is not needed for intestinal microvillar morphogenesis, as shown in knockout mice devoid of microvillar actin-bundling proteins. This architecture is essential for the apical anchorage of digestive proteins, probably via the recruitment of key players in apical retention, such as myosin-1a, and, as a result, for intestinal physiology

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Publisher: The American Society for Cell Biology

OAI identifier: oai:pubmedcentral.nih.gov:3258176

Provided by: PubMed Central

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A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

Abstract

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