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Gap junction assembly: roles for the formation plaque and regulation by the C-terminus of connexin43

By Ross G. Johnson, James K. Reynhout, Erica M. TenBroek, Bradley J. Quade, Thomas Yasumura, Kimberly G. V. Davidson, Judson D. Sheridan and John E. Rash


Gap junction (GJ) “formation plaques” are distinct membrane domains with GJ precursors; they assemble by means of a series of defined steps. The C-terminus of Cx43 is required for normal progression of assembly, normal aggregation of 10-nm particles into small GJs, and negative regulation of assembly involving protein kinase C

Topics: Articles
Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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