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Can premorbid episodes of diminished vagal tone be detected via histological markers in patients with PTSD?

By Dr. Stefan Bracha


While laboratory methods for estimating genetic susceptibility for adult psychopathology have received much recent attention, laboratory methods for objectively estimating a person’s early autonomic nervous system perturbations have been under-researched. Research on heart rate variability suggests that early life episodes of diminished vagal tone may predict poor stress resilience in adults. This article will detail a research method for retrospectively estimating in adults the chronology of diminished vagal tone episodes experienced prior to age 10. This method makes use of the developing enamel matrix, one of very few tissues that cannot recover after being stressed

Topics: Clinical Psychology
Year: 2004
OAI identifier:

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  3. (1995). Cardiac vagal tone: a physiological index of stress.
  4. (1994). Children with hypoplastic enamel defects of primary incisors are not at increased risk of learning-problem syndromes.
  5. (1979). Classification and prevalence of enamel opacities in the human deciduous and permanent dentitions.
  6. (2003). Clinical research histomarkers for objectively estimating premorbid vagal tone chronology in Gulf war veterans’ illnesses and in acute stress reaction. In: Nation,
  7. (1979). Deciduous teeth contain histories of developmental disturbances.
  8. (1996). Dental Anthropology.
  9. (1999). Dental morphology
  10. (1941). Developmental pattern of the child as reflected in the calcification pattern of the teeth.
  11. (1987). Hearing and neurologic impairment: insult timing indicated by primary tooth enamel defects.
  12. (1999). Hominoid tooth growth: using incremental lines in dentine as markers of growth in modern human and fossil primate teeth.
  13. (1991). Human Osteology. doi
  14. (1996). Neural sensitization and physiological markers in multiple chemical sensitivity.
  15. (1990). Stresses of conquest: a study of Wilson bands and enamel hypoplasias in the Maya of Lamanai, doi
  16. (2003). Stressful experiences in children and adolescents: Initial report from the PSEI-NCPV Honolulu study. Hawaii Med.
  17. (2001). The Anatomical Basis of Dentistry. 2nd ed.
  18. (1990). The Autonomic Nervous System: an Introduction to Basic and Clinical Concepts.
  19. (1998). The Cambridge Encyclopedia of Human Paleopathology.
  20. (1981). The human central nervous system. A Synopsis and Atlas. 2nd ed.
  21. (2003). The relevance of differential response to trauma in an animal model of posttraumatic stress disorder.
  22. (1970). The significance of developmental dental enamel defects in neurological diagnosis.

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