Article thumbnail

Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation

By María Verónica Baez, Luciana Luchelli, Darío Maschi, Martín Habif, Malena Pascual, María Gabriela Thomas and Graciela Lidia Boccaccio

Abstract

S-foci, the first reported mRNA-silencing foci specific to neurons, may control local mRNA translation in response to NMDA receptor stimulation and synaptic plasticity

Topics: Research Articles
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:3246892
Provided by: PubMed Central

Suggested articles

Citations

  1. (2008). A loss of func tion allele for murine Staufen1 leads to impairment of dendritic Staufen1 RNP delivery and dendritic spine morphogenesis.
  2. (2007). An RNAi based approach identifies molecules required for glutamatergic and GABAergic synapse development.
  3. (2010). CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action.
  4. (1998). CPEBmediated cytoplas mic polyadenylation and the regulation of experiencedependent trans lation of alphaCaMKII mRNA at synapses.
  5. (2006). Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules.
  6. (2008). Dynamic interaction between Pbodies and transport ribonucleoprotein particles in dendrites of mature hippo campal neurons.
  7. (2001). Dynamic visualization of local protein synthesis in hippocampal neurons.
  8. (2008). Huntington’s disease protein contributes to RNAmediated gene silencing through association with Argonaute and P bodies.
  9. (2006). Identification of processlocalized mRNAs from cultured rodent hippo campal neurons.
  10. (2011). Independent localization of MAP2, CaMKII and actin RNAs in low copy numbers. EMBO Rep. 12:1077–1084. http://dx.doi.org/10.1038/embor.2011.149
  11. (2005). Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.
  12. (2009). Mammalian Staufen 1 is recruited to stress granules and impairs their assembly.
  13. (1999). Microtubuledependent recruitment of Staufengreen fluorescent protein into large RNAcontaining granules and subsequent dendritic transport in living hippocampal neurons.
  14. (2009). mRNA localization: gene expres sion in the spatial dimension.
  15. (2010). On track with Pbodies.
  16. (1996). Protein synthesis within dendrites: ionic and neurotransmitter modulation of synthesis of particular polypeptides char acterized by gel electrophoresis.
  17. proteins that cause amyotrophic lateral sclerosis incorpo rate into stress granules.
  18. (2011). published erratum appears in PLoS ONE.
  19. (2010). regulates dendrite morphogenesis and synaptic function.
  20. (2011). Smaug assembles an ATPdependent stable complex repressing nanos mRNA translation at multiple levels.
  21. (1999). Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro.
  22. (2006). Staufen and FMRPcontaining neuronal RNPs are structurally and function ally related to somatic P bodies.
  23. (2005). Staufen recruitment into stress gran ules does not affect early mRNA transport in oligodendrocytes.
  24. (2010). Tar DNA binding protein43 (TDP43) associates with stress granules: analy sis of cultured cells and pathological brain tissue. PLoS ONE.
  25. (2008). TDP43, the signature protein of FTLDU, is a neuronal activityresponsive factor.
  26. (2005). The RNA binding pro tein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
  27. (2003). The RNAbinding SAM domain of Smaug defines a new family of post transcriptional regulators.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.