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A randomized controlled trial of isotonic versus hypotonic maintenance intravenous fluids in hospitalized children

By Thomas G Saba, James Fairbairn, Fiona Houghton, Diane Laforte and Bethany J Foster
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2000). [Severe hyponatremic encephalopathy after pediatric surgery: report of seven cases and recommendations for management and prevention]. Ann Fr Anesth Reanim
  2. (2001). A: La Crosse encephalitis in children.
  3. (2003). A: Reducing errors in fluid therapy management. Pediatrics
  4. (2004). Acute hyponatremia related to intravenous fluid administration in hospitalized children: an observational study. Pediatrics
  5. (2008). Ayus JC: 0.9% saline solution for the prevention of hospitalacquired hyponatremia: why is there still doubt?
  6. (2004). Ayus JC: Hospital-acquired hyponatremia: why are there still deaths? Pediatrics
  7. (2005). Ayus JC: Preventing neurological complications from dysnatremias in children. Pediatr Nephrol
  8. (2003). Ayus JC: Prevention of hospital-acquired hyponatremia: a case for using isotonic saline. Pediatrics
  9. (1992). CL: Hyponatraemia and death or permanent brain damage in healthy children. BMJ
  10. (1994). Clinical Physiology of Acid-Base and Electrolyte Disorders.
  11. Clinical Physiology of Acid-Base Disorders.
  12. (2001). DR: Normal saline versus lactated Ringer’s solution for intraoperative fluid management in patients undergoing abdominal aortic aneurysm repair: an outcome study. Anesth Analg
  13. (2003). Fatal iatrogenic hyponatraemia. Arch Dis Child
  14. Finberg L: Intravenous fluids for seriously ill children. Lancet 2004, 363(9404):241; author reply
  15. (2007). Hypotonic versus isotonic maintenance intravenous fluid therapy in hospitalized children: a systematic review. Clin Pediatr (Phila)
  16. (2006). Hypotonic versus isotonic saline in hospitalised children: a systematic review. Arch Dis Child
  17. (1976). IB: Inappropriate secretion of antidiuretic hormone in postoperative scoliosis patients: the role of fluid management. Spine (Phila Pa
  18. (2003). Intravenous fluids for seriously ill children: time to reconsider. Lancet
  19. (2006). JL: Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study. Arch Dis Child
  20. (2009). JL: Prevention of Hyponatremia during Maintenance Intravenous Fluid Administration: A Prospective Randomized Study of Fluid Type versus Fluid Rate.
  21. (2001). MG: The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg
  22. (2008). MJ: Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions.
  23. (1997). ML: Postoperative hyponatremia despite near-isotonic saline infusion: a phenomenon of desalination. Ann Intern Med
  24. Patient Safety Agency Alert NPSA/2007/22.
  25. (2009). Randomised controlled trial of intravenous maintenance fluids.
  26. (2001). Rationale for early feeding in childhood gastroenteritis.
  27. (2004). Rubbing salt in the wound. Arch Dis Child
  28. (1991). Savir I: Symptomatic hyponatraemia due to inappropriate antidiuretic hormone secretion following minor surgery.
  29. (1957). Segar WE: The maintenance need for water in parenteral fluid therapy. Pediatrics
  30. (2008). The problem of acute hyponatremia in hospitalized children: the solution is in the solution. Pediatr Crit Care Med
  31. (2008). Toledo Parreno JD: The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med
  32. (2010). Treatment of hypovolemia (dehydration) in children.
  33. (2008). Urine sodium composition in ambulatory healthy children: hypotonic or isotonic? Pediatric Nephrology
  34. (2007). WE: Nelson textbook of pediatrics.
  35. (1994). Weissburg AJ, Chang KW: Iatrogenic hyponatremia: a cause of death following pediatric tonsillectomy.

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