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Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion

By John M. Perry, Xi C. He, Ryohichi Sugimura, Justin C. Grindley, Jeffrey S. Haug, Sheng Ding and Linheng Li


Li and colleagues investigated the mechanism of stem cell self-renewal using compound mutant mice. The mutation in hematopoietic stem cells combines a Pten deletion and activated β-catenin and demonstrates that activation of either Wnt/β-catenin or PI3K/Akt signaling is not sufficient to expand primitive HSCs, but in combination, both pathways drive self-renewal and expansion of HSCs with long-term functional capacity

Topics: Research Paper
Publisher: Cold Spring Harbor Laboratory Press
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Provided by: PubMed Central
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