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ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study

By Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang and Dianjun Li
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2007). al: Genomewide association study identifies novel breast cancer susceptibility loci. Nature
  2. (2008). An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat
  3. (1999). Anagnostopoulos I, Kroczek RA: ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature
  4. (2009). Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. Transplantation
  5. (2005). Baralle M: Splicing in action: assessing disease causing sequence changes.
  6. (2008). C: The resource: targets and expression. Nucleic Acids Res
  7. (2001). Coyle AJ: ICOS is critical for T helper cellmediated lung mucosal inflammatory responses. Nat Immunol
  8. (2004). Dehaghani AS: Cytotoxic T lymphocyte antigen-4 gene in breast cancer. Breast Cancer Res Treat
  9. (2002). Distribution and characterization of regulatory elements in the human genome. Genome Res
  10. (2005). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet
  11. (2008). Forsti A: Polymorphisms in predicted microRNAbinding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis
  12. (2007). Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4. Mol Immunol
  13. Immune responses to malignancies.
  14. (2007). IO: Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype.
  15. (2010). Li D: Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province. Breast Cancer Res Treat
  16. (2003). Lillevang ST: Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. Tissue Antigens
  17. (2006). MN: HER2 and responsiveness of breast cancer to adjuvant chemotherapy.
  18. (2001). Molecular biomarkers for breast cancer prognosis: coexpression of c-erbB-2 and p53. Ann Surg
  19. (2009). Morio T: Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients.
  20. (2008). Oaks MK: Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms.
  21. (2009). of 7nonmalignant and malignant prostate tissues. Proc Natl Acad Sci USA
  22. (2001). Ozkaynak E, Coyle AJ: The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol
  23. (2008). P: CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA
  24. (2010). Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis? Cancer Immunol Immunother
  25. (1993). Pre-mRNA secondary structure and the regulation of splicing. Bioessays
  26. (2006). PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res
  27. (2001). RA: ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature
  28. (2002). RD: Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol
  29. (2006). Regulation of gene expression by alternative untranslated regions. Trends Genet
  30. (2009). TF: Costimulatory and coinhibitory receptors in anti-tumor immunity. Immunol Rev
  31. (2006). Wu MS: Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma.
  32. (2009). Yang YC: Functional polymorphism of CTLA4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. Clin Chim Acta