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The activation of ezrin–radixin–moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1–induced axon outgrowth

By Judith Antoine-Bertrand, Atefeh Ghogha, Vilayphone Luangrath, Fiona K. Bedford and Nathalie Lamarche-Vane


The axon guidance cue netrin-1 and its receptor DCC regulate axon outgrowth. Netrin-1 induces the activation of ERM proteins and their association with DCC in cortical neurons, and the activity of ERM proteins is required for netrin-1–dependent axon outgrowth

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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