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Current research in child and adolescent bipolar disorder

By Christine A. Demeter, Lisa D. Townsend, Michael Wilson and Robert L. Findling

Abstract

Although recently more research has considered children with bipolar disorder than in the past, much controversy still surrounds the validity of the diagnosis. Furthermore, questions remain as to whether or not childhood expressions of bipolarity are continuous with adult manifestations of the illness. In order to advance current knowledge of bipolar disorders in children, researchers have begun to conduct phenomenological, longitudinal, treatment, and neuroimaging studies in youths who exhibit symptoms of bipolar illness, as well as offspring of parents with bipolar disorders. Regardless of the differences between research groups regarding how bipolar disorder in children is defined, it is agreed that pediatric bipolarity is a serious and pernicious illness. With early intervention during the period of time in which youths are exhibiting subsyndromal symptoms of pediatric bipolarity, it appears that the progression of the illness to the more malignant manifestation of the disorder may be avoided. This paper will review what is currently known and what still is left to learn about clinically salient topics that pertain to bipolar disorder in children and adolescents

Topics: Clinical Research
Publisher: Les Laboratoires Servier
OAI identifier: oai:pubmedcentral.nih.gov:3181873
Provided by: PubMed Central

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  1. A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents.
  2. A doubleblind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania.
  3. A pilot controlled trial of topiramate for mania in children and adolescents with bipolar disorder.
  4. A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder.
  5. (2007). A prospective open-label treatment trial of ziprasidone monotherapy in children and adolescents with bipolar disorder. Bipolar Disord.
  6. Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task.
  7. (2006). Adapting interpersonal and social rhythm therapy to the developmental needs of adolescents with bipolar disorder. Dev Psychopathol.
  8. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry.
  9. Ages of onset and rates of syndromal and subsyndromal comorbid DSMIV diagnoses in a prepubertal and early adolescent bipolar disorder phenotype.
  10. (2007). Aggression, hostility, and irritability in children at risk for bipolar disorder. Bipolar Disord.
  11. Akiskal HS. Preschool-onset mania: incidence, phenomenology and family history.
  12. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry.
  13. An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression.
  14. Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder.
  15. and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary results.
  16. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry.
  17. (1993). Antecedents of severe affective (mood) disorders. Patients examined as children or adolescents and as adults. Acta Paedopsychiatr.
  18. Anterior cingulate volume in pediatric bipolar disorder and autism.
  19. Anticipation and repeat expansion in bipolar disorder.
  20. Bipolar disorder during adolescence and young adulthood in a community sample. Bipolar Disord.
  21. (2003). Bipolar offspring: a window into bipolar disorder evolution. Biol Psychiatry.
  22. (2004). Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry.
  23. (2007). Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry.
  24. Child comorbidity, maternal mood disorder, and perceptions of family functioning among bipolar youth.
  25. Childhood-onset bipolar disorder: Evidence for increased familial loading of psychiatric illness.
  26. Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder.
  27. Clinical characteristics of bipolar disorder in very young children.
  28. Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents.
  29. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry.
  30. Clozapine in adolescent inpatients with acute mania.
  31. Clozapine treatment of children and adolescents with bipolar disorder and schizophrenia: a clinical case series.
  32. Co-occurrence of bipolar and attention-deficit hyperactivity disorders in children. Bipolar Disord.
  33. Cognitive flexibility in phenotypes of pediatric bipolar disorder.
  34. Cognitive-behavioral therapy for bipolar disorders in adolescents: a pilot study. Bipolar Disord.
  35. Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization.
  36. Combination lithium and divalproex sodium in pediatric bipolarity.
  37. Combination pharmacotherapy in children and adolescents with bipolar disorder. Biol Psychiatry.
  38. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.
  39. Comorbid anxiety in phenotypes of pediatric bipolar disorder.
  40. (2007). COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord.
  41. Consensus report on impulsive aggression as a symptom across diagnostic categories in child psychiatry: implications for medication studies.
  42. continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disord.
  43. Controlled study of switching from attentiondeficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors. Dev Psychopathol.
  44. (2005). Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disord.
  45. (2006). Course and outcome of bipolar spectrum disorder in children and adolescents: a review of the existing literature. Dev Psychopathol.
  46. Deficits in social cognition and response flexibility in pediatric bipolar disorder.
  47. (2006). Defining and validating bipolar disorder in the preschool period. Dev Psychopathol.
  48. DelBello MP. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder.
  49. (1996). Developmental psychobiology of cyclic affective illness: implications for early therapeutic intervention. Dev Psychopathol.
  50. Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trial.
  51. Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorder.
  52. Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness.
  53. (2007). Early identification and high-risk strategies for bipolar disorder. Bipolar Disord.
  54. Early symptoms of mania and the role of parental risk. Bipolar Disord.
  55. (2000). Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder.
  56. (2007). Efficacy of aripiprazole in children (10-17 years old) with mania. Paper presented at:
  57. (2007). Efficacy of quetiapine in children and adolescents with bipolar mania: a 3-week, double-blind, randomized, placebo-controlled trial. Paper presented at:
  58. Facial expression recognition in adolescents with mood and anxiety disorders.
  59. Familiality of polarity at illness onset in bipolar affective disorder.
  60. Family-focused treatment for adolescents with bipolar disorder.
  61. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry.
  62. Further evidence for a developmental subtype of bipolar disorder defined by age at onset: results from the national epidemiologic survey on alcohol and related conditions.
  63. (2004). Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years. J Affect Disord.
  64. (2007). Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates. Mol Psychiatry.
  65. Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex.
  66. History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk. Bipolar Disord.
  67. (1997). Is comorbidity with ADHD a marker for juvenile-onset mania? J Am Acad Child Adolesc Psychiatry.
  68. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry.
  69. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry.
  70. Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder.
  71. (2001). Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. Arch Gen Psychiatry.
  72. Lithium treatment of acute mania in adolescents: a large open trial.
  73. Lithium treatment of acute mania in adolescents: a placebo-controlled discontinuation study.
  74. (2004). Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEPBD). Biol Psychiatry.
  75. Maintenance model of integrated psychosocial treatment in pediatric bipolar disorder: A pilot feasibility study.
  76. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry.
  77. Molecular genetics of bipolar disorder.
  78. Mood disorders in children and adolescents: an epidemiologic perspective. Biol Psychiatry.
  79. (2007). MTHFD 1958G>A and MTR 2756A>G polymorphisms are associated with bipolar disorder and schizophrenia. Psychiatr Genet.
  80. (2007). National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry.
  81. Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder.
  82. Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit.
  83. Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord.
  84. Neuroimaging studies of children with serious emotional disturbances: a selective review.
  85. Olanzapine versus placebo in the treatment of adolescents with bipolar mania.
  86. Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial.
  87. Open-label lithium for the treatment of adolescents with bipolar depression.
  88. (2004). Open-label prospective trial of risperidone in combination with lithium or divalproex sodium in pediatric mania. J Affect Disord.
  89. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children. Biol Psychiatry.
  90. (2007). Pediatric Bipolar Collaborative Mood Stabilizer Trial. Paper presented at:
  91. (2005). Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry.
  92. (2004). Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord.
  93. (2006). Phenomenology and diagnosis of bipolar disorder in children, adolescents, and adults: complexities and developmental issues. Dev Psychopathol.
  94. (2006). Phenomenology of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry.
  95. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder.
  96. Progressive gray matter loss in patients with bipolar disorder. Biol Psychiatry.
  97. Psychiatric phenomenology of child and adolescent bipolar offspring.
  98. (2006). Psychoeducational treatment for school-aged children with bipolar disorder. Dev Psychopathol.
  99. Psychopathology in children of bipolar parents.
  100. (2005). Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biol Psychiatry.
  101. (2006). Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study. Psychiatry Res.
  102. Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype.
  103. (1995). Recovery and relapse in adolescents with bipolar affective illness: a five-year naturalistic, prospective follow-up. J Am Acad Child Adolesc Psychiatry.
  104. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder.
  105. Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disord.
  106. (2007). Risperidone for the treatment of acute mania in bipolar youth. Paper presented at:
  107. (2007). Safety and efficacy of divalproex ER in youth with mania. Paper presented at:
  108. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder.
  109. The genetics of bipolar affective disorder. Curr Opin Psychiatry.
  110. (1990). The Genetics of Mood Disorders.
  111. (2001). The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord.
  112. The poor prognosis of childhood-onset bipolar disorder.
  113. Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania.
  114. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord.
  115. Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode.
  116. Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry.
  117. Update on lithium carbonate therapy in children and adolescents.
  118. (2006). Ziprasidone dosing study in pediatric patients with bipolar disorder, schizophrenia, or schizoaffective disorder. Paper presented at: Association of European Psychiatrists'
  119. Ziprasidone monotherapy in pediatric bipolar disorder.