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Clinicians’ predictions of patient response to psychotropic medications

By Pierre Schulz and Patricia Berney


Clinicians prescribe a medication when they assume that there is a reasonable probability of its success. There are many studies on the predictive value of social or clinical information, but these studies do not include the prognosis made by psychiatrists before treatment. These studies indicate that a small to moderate proportion of the total variance of outcome can be predicted from social or clinical information. It is peculiar that there are very few studies on the accuracy of psychiatrists’ “bets” about the effects of psychotropic drugs when they use the clinical characteristics of patients as predictors, considering the practical relevance of predicting the outcome of a psychiatric treatment. The absence of studies on the accuracy of clinicians’ bets or predictions in psychiatry is unfortunate

Topics: Clinical Research
Publisher: Les Laboratoires Servier
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Provided by: PubMed Central

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  10. Emmelkamp PMG. Prediction of treatment outcome in social phobia: a cross-validation. Behav Res Ther.
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  12. (1999). Long-term outcome of hypochondriacal personality disorder. J Psychosom Res.
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  17. (1998). Personality disorder comorbidity with major depression and response to treatment with sertraline or citalopram. Int Clin Psychopharmacol.
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  20. (1998). Predicting outcome of treatment.
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  22. (1980). Predicting the outcome of psychotherapy. Findings of the Penn Psychotherapy Project. Arch Gen Psychiatry.
  23. Prediction of 5-year survival for patients admitted to a department of internal medicine.
  24. (1981). Prediction of outcome in anorexia nervosa from neuropsychological status. Psychiatry Res.
  25. (1998). Prediction of outcome in neurotic disorder: a 5-year prospective study. Psychol Med.
  26. (1979). Prediction of survival in patients with acute myocardial infarction. A clinical study on 100 consecutive patients. Acta Med Scand.
  27. Prediction outcome in treatment of alcoholism: a study of staff and patients.
  28. Predictions made by psychiatrists and psychiatric nurses of violence by patients. Psychiatry Serv.
  29. Predictors of outcome following venlafaxine extended-release treatment of DSM-IV generalized anxiety disorder: a pooled analysis of short- and long-term studies.
  30. Predictors of treatment outcome in young children with autism: a retrospective study.
  31. (1999). Prognostic methods in medicine. Artif Intell Med.
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  35. The inability of physicians to predict the outcome of in-hospital resuscitation.
  36. The prediction of nonresponse to pharmacotherapy in panic disorder: a review. Depress Anxiety.
  37. The relationship of personality disorders to treatment outcome in depressed outpatients.