Article thumbnail

The CPT1C 5′UTR Contains a Repressing Upstream Open Reading Frame That Is Regulated by Cellular Energy Availability and AMPK

By Ines Lohse, Patrick Reilly and Kathrin Zaugg
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3178533
Provided by: PubMed Central

Suggested articles

Citations

  1. (2002). A novel brain-expressed protein related to carnitine palmitoyltransferase I.
  2. (2005). Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy.
  3. (2010). AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci
  4. (2004). AMP-activated protein kinase: a master switch in glucose and lipid metabolism.
  5. (2010). AMPK as a mediator of hormonal signalling.
  6. (1998). An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.
  7. (2008). Brain-specific carnitine palmitoyltransferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.
  8. (2004). Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.
  9. (1999). Control of Food Intake by Fatty Acid Oxidation and Ketogenesis.
  10. (2008). CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
  11. (2003). Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport.
  12. (2006). Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain.
  13. (2002). Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides.
  14. (2009). Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a hightfat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake.
  15. (2000). Evidence for Translational Repression of the SOCS-1 Major Open Reading Frame by an Upstream Open Reading Frame. Biochemical and Biophysical Research Communications 268: 255–261. CPT1C 59UTR Is Responsive to Energy and
  16. (2004). Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes.
  17. (2007). Fatty acid sensing and nervous control of Energy homeostasis.
  18. Geballe AP (2000) Upstream open reading frames as regulators of mRNA translation.
  19. (2006). her-2 upstream open reading frame effects on the use of downstream initiation codons.
  20. (2003). Hypothalamic malonyl-CoA as a mediator of feeding behaviour.
  21. (2010). Influence of ghrelin and GH deficiency on AMPK and hypothalamic lipid metabolism.
  22. (2003). Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production.
  23. Lane MD (2006a) The role of hypothalamic malonyl-CoA in energy homeostasis.
  24. Lane MD (2006b) Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system.
  25. (2007). Localization and effect of ectopic expression of CPT1c in CNS feeding centers.
  26. (2009). Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis.
  27. (2006). Metformin Inhibits Adenosine 59-Monophosphate-Activated Kinase Activation and Prevents Increases in Neuropeptide Y Expression in Cultured Hypothalamic Neurons.
  28. (2006). Molecular disruption of hypothalamic nutrient sensing induces obesity.
  29. (1999). Mutation of the CDKN2A 59 UTR creates an aberrant initiation codon and predisposes to melanoma.
  30. (1983). Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat.
  31. (2010). Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 59 monophosphateactivated protein kinase activation.
  32. (1999). Palmitate induces apoptosis via a direct effect on mitochondria.
  33. (2009). Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
  34. (2008). Recognition and elemination of nonsense mRNA.
  35. (2006). Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells.
  36. (1999). Regulation of Gene Expression by Dietary Fat.
  37. (2008). Role of hypothalamic AMP-kinase in food intake regulation.
  38. (1991). Structural features in eukaryotic mRNAs that modulate the initiation of translation.
  39. (2009). Succrose control of translation mediated by an upstream open reading frame-encoded peptide.
  40. (2009). The 59 adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics.
  41. (2006). The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis.
  42. (2009). Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.