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Hypertension and cerebral white matter lesions in a prospective cohort study

By Frank Leeuw, Jan Cees Groot, Matthijs Oudkerk, Jacqueline Witteman, Jan Gijn, Monique Breteler and Albert Hofman


White matter lesions are frequently found on cerebral MRI scans of elderly people and are thought to be important in the pathogenesis of dementia. Hyper tension has been associated with the presence of white matter lesions but this has been investigated almost exclusively in cross-sectional studies. We studied prospectively the association of these lesions with the duration and treatment of hypertension. We randomly sampled 1077 subjects aged between 60 and 90 years from two prospective population-based studies. One-half of the study subjects had their blood pressure measured between 1975 and 1978 and the other half between 1990 and 1993. All subjects underwent 1.5 T MRI scanning; white matter lesions in the subcortical and periventricular regions were rated separately. Subjects with hypertension had increased rates of both types of white matter lesion. Duration of hypertension was associated with both periventricular and subcortical white matter lesions. This relationship was influenced strongly by age. For participants with >20 years o

Topics: Age Factors, Age of Onset, Aged, Aged, 80 and over, Antihypertensive Agents/therapeutic use, Cerebral Cortex/*pathology/physiopathology, Cohort Studies, Dementia, Vascular/*etiology/*pathology/physiopathology, Disease Progression, Female, Humans, Hypertension/*complications/drug therapy, Magnetic Resonance Imaging, Male, Middle aged, Nerve Fibers, Myelinated/*pathology, Prospective Studies, Research Support, Non-U.S. Gov't, Risk Factors
Year: 2002
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Provided by: NARCIS
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