Article thumbnail

LEDGF1-326 Decreases P23H and Wild Type Rhodopsin Aggregates and P23H Rhodopsin Mediated Cell Damage in Human Retinal Pigment Epithelial Cells

By Rinku Baid, Robert I. Scheinman, Toshimichi Shinohara, Dhirendra P. Singh and Uday B. Kompella
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1989). A donor-age-dependent change in the activity of alpha-mannosidase in human cultured RPE cells.
  2. (1999). A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.
  3. (2002). A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system.
  4. (2003). Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells.
  5. (1995). Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration.
  6. (2006). DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the Nterminal to the trans-activation potential of LEDGF.
  7. (1998). Histopathology of the human retina in retinitis pigmentosa.
  8. (2003). HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.
  9. (2001). LEDGF binds to heat shock and stress-related element to activate the expression of stressrelated genes.
  10. (2004). LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity.
  11. (2003). LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.
  12. (2001). Lens epithelium-derived growth factor promotes photoreceptor survival in lightdamaged and RCS rats.
  13. (2003). Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells.
  14. (2005). Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.
  15. (1999). Morphological, physiological, and biochemical changes in rhodopsin knockout mice.
  16. (1998). Neovascularization of the RPE: temporal differences in mice with rod photoreceptor gene defects.
  17. (2009). Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism.
  18. (1995). Retinal degeneration caused by dominant rhodopsin mutations in Drosophila.
  19. (2002). Rhodopsin and retinitis pigmentosa: shedding light on structure and function.
  20. (1993). Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain.
  21. (1994). Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa.
  22. (2002). The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.
  23. (2005). The retinal pigment epithelium in visual function.
  24. (2000). The small heat-shock chaperone protein, alpha-crystallin, does not recognize stable molten globule states of cytosolic proteins.
  25. (2006). The use of GFP to localize Rho GTPases in living cells.