Article thumbnail

Paradoxical euthyroid hormone profile in a case of Graves' disease with cardiac failure

By Ganesh Jevalikar, Priyanka Gupta, Vijayalakshmi Bhatia, Aditya Kapoor and Sanjay Gambhir


Cardiac failure is an uncommon complication of juvenile hyperthyroidism. We describe an adolescent boy with Graves' disease who developed manifestations of heart failure while on antithyroid medications. There was no evidence of any underlying cardiac disease. He had paradoxical euthyroid hormone profile which rose to hyperthyroid range when the manifestations of the cardiac failure subsided. The case highlights several unusual features of Graves' disease

Topics: Case Report
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1984). Casta A: Cardiac complications in juvenile hyperthyroidism.
  2. (1980). Chapman C: Thyroid function tests during carbimazole therapy.
  3. Endocrine disorders and the cardiovascular system. In Braunwald’s Heart Disease: A Textbook of Cardiovascular System.. 8 edition. Edited by: Libby
  4. (2002). Hryniewicz K: Thyroid hormone metabolism in patients with congestive heart failure: The low triiodothyronine state. Thyroid
  5. (2008). ID: Thyroid hormones in peripheral tissues.
  6. (1988). JM: The hematology of hyperthyroidism: abnormalities of erythrocytes, leucocytes, thrombocytes and haemostasis.
  7. (1986). KL: Heart failure in sinus rhythm as the sole manifestation of Graves’ disease.
  8. (1999). LJ: Dangerous dogmas in medicine: the nonthyroidal illness Syndrome.
  9. (2010). Mechanisms behind the non-thyroidal illness syndrome: an update.
  10. (1983). Nicoloff JT: Influence of nonthyroidal illnesses on serum thyroid hormone indices in hyperthyroidism. The Western Journal of Medicine
  11. (2001). Ojamaa K: Thyroid hormone and the cardiovascular system.
  12. Pinchera A: Graves’ disease. In Endocrinology.
  13. (1996). PM: Treatment of thyrotoxicosis resistant to carbimazole with corticosteroids.
  14. (2007). Reversible pulmonary hypertension and isolated right-sided heart failure associated with hyperthyroidism.
  15. (1995). Splenomegaly in 2,505 patients at a large university medical center from 1913 to
  16. (1996). Tavazzi L: Sick euthyroid syndrome in patients with moderate-to-severe chronic heart failure.
  17. (2006). Thyrotoxicosis and thyroid storm. Endocrinology and Metabolism Clinics of North America
  18. (2007). Tse HF: Hemodynamic changes in hyperthyroidism-related pulmonary hypertension: A prospective echocardiographic study.
  19. (2007). Tse HF: Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart
  20. (1988). Tsila Zwas S: Graves’ disease presenting as pyrexia of unknown origin.
  21. (1985). WJ: Is there a thyrotoxic cardiomyopathy in children? The Journal of Pediatrics