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Cyclophilin E Functions as a Negative Regulator to Influenza Virus Replication by Impairing the Formation of the Viral Ribonucleoprotein Complex

By Zengfu Wang, Xiaoling Liu, Zhendong Zhao, Chongfeng Xu, Ke Zhang, Caiwei Chen, Lei Sun, George F. Gao, Xin Ye and Wenjun Liu
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  1. (2005). 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase.
  2. (1996). A nuclear RNA-binding cyclophilin in human T cells.
  3. (1987). Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.
  4. (1987). Assembly of influenza ribonucleoprotein in vitro using recombinant nucleoprotein.
  5. (2006). Avian flu: influenza virus receptors in the human airway.
  6. (2006). Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.
  7. (2011). Chicken cyclophilin A is an inhibitory factor to influenza virus replication.
  8. (2010). Comparative distribution of human and avian type sialic acid influenza receptors in the pig.
  9. (2009). Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication.
  10. (2008). Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro.
  11. (2009). Differences in influenza virus receptors in chickens and ducks: Implications for interspecies transmission.
  12. (2011). Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus.
  13. (1969). Distinct subunits of the ribonucleoprotein of influenza virus.
  14. (2010). Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities.
  15. (1993). Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
  16. (2006). Human trachea primary epithelial cells express both sialyl(alpha2–3)Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl(alpha2– 6)Gal receptor for human influenza viruses.
  17. (1999). Identification of amino acid residues of influenza virus nucleoprotein essential for RNA binding.
  18. (2006). Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle.
  19. (2007). IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
  20. (1998). Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 39end formation of cellular pre-mRNAs.
  21. (1998). Influenza virus nucleoprotein interacts with influenza virus polymerase proteins.
  22. (2008). Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus.
  23. (2011). Interaction of the influenza A virus polymerase PB2 Cterminal region with importin {alpha} isoforms provides insights into host adaptation and polymerase assembly.
  24. (2001). Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway.
  25. (1969). Isolation and characterization of the ribonucleoprotein of influenza virus.
  26. (1988). Localization of RNA polymerases on influenza viral ribonucleoproteins by immunogold labeling.
  27. (1999). Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments.
  28. Murata T,etal.(2005) CyclophilinB isa functional regulator of hepatitis C virus RNA polymerase.
  29. (2009). Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein.
  30. (2009). Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein.
  31. (1995). Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import.
  32. (1995). Portela A
  33. (2003). Quantification of CCR5 mRNA in human lymphocytes and macrophages by real-time reverse transcriptase PCR assay.
  34. (1990). Reconstitution of influenza virus RNA-nucleoprotein complexes structurally resembling native viral ribonucleoprotein cores.
  35. SaitohT,YamamotoM,Miyagishi M,Taira K,NakanishiM,etal.(2005) A20isa negativeregulatorofIFNregulatoryfactor3signaling.JImmunol174:1507–1512.
  36. (1969). Some Properties of Influenza Virus Nucleocapsids.
  37. (1994). Specific incorporation of cyclophilin A into HIV-1 virions.
  38. (1995). Structure of influenza virus ribonucleoprotein particles. II. Purified RNA-free influenza virus ribonucleoprotein forms structures that are indistinguishable from the intact influenza virus ribonucleoprotein particles.
  39. (1999). Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein.
  40. (2007). The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism.
  41. (1977). The genes of influenza virus.
  42. (2002). The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.
  43. (2006). The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA.
  44. (2006). The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 29–59 oligo (A) synthetase/RNase L pathway.
  45. (2009). The structure of a biologically active influenza virus ribonucleoprotein complex.
  46. (2010). Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.