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The nervous principle: active versus passive electric processes in neurons

By Danko Georgiev

Abstract

This essay presents in the first section a comprehensive introduction to classical electrodynamics. The reader is acquainted with some basic concepts like right-handed coordinate system, vector calculus, particle and field fluxes, and learns how to calculate electric and magnetic field strengths in different neuronal compartments. Then the exposition comes to explain the basic difference between a passive and an active neural electric process; a brief historical perspective on the nervous principle is also provided. A thorough description is supplied of the nonlinear mechanism generating action potentials in different compartments, with focus on dendritic electroneurobiology. Concurrently, the electric field intensity and magnetic flux density are estimated for each neuronal compartment. Observations are then discussed, succinctly as the calculated results and experimental data square. Local neuronal magnetic flux density is less than 1/300 of the Earth’s magnetic field, explaining why any neuronal magnetic signal would be suffocated by the surrounding noise. In contrast the electric field carries biologically important information and thus, as it is well known, acts upon voltage-gated transmembrane ion channels that generate neuronal action potentials. Though the transmembrane difference in electric field intensity climbs to ten million volts per meter, the intensity of the electric field is estimated to be only ten volts per meter inside the neuronal cytoplasm

Topics: Biophysics, Neural Modelling, Neurophysiology
Year: 2004
OAI identifier: oai:cogprints.org:3938
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    Citations

    1. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. doi
    2. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites.
    3. (2000). Calciumdependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons.
    4. (1989). Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.
    5. (1884). Contribución al estudio de las Localizaciones Cerebrales y a la Patogénesis de la Epilepsia.
    6. (1886). Contribución al estudio de las Localizaciones Cerebrales y a la Patogénesis de la Epilepsia. Buenos Aires,
    7. (1952). Currents carried by the sodium and potassium ion through the membrane of the giant axon of Loligo.
    8. (1999). Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons.
    9. (1996). Dendritic Na+ channels amplify EPSPs in hippocampal CA1 pyramidal cells.
    10. (2001). Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites.
    11. (2000). Differential distribution of three Ca2+-activated K+ channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system.
    12. (2000). Distant synapses raise their voices.
    13. (1980). Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.
    14. (1961). Electrophysiology of the hippocampal neurons. IV. Fast prepotentials.
    15. (1971). Electroresponsive properties of dendrites and somata in alligator Purkinje cells.
    16. (1980). Engramación por islotes de electreto: estudio experimental de su posibilidad como mecanismo neural.
    17. (1840). Essai sur les phénomènes électriques des animaux.
    18. (2002). Focal stimulation of single GABAergic presynaptic boutons on the rat hippocampal neuron.
    19. (1985). Gradient, ∇ " and "Successive Applications of ∇ ."
    20. (2003). Gradient. Wolfram Research, Inc. Web source: http://mathworld.wolfram.com/Gradient.html
    21. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. doi
    22. (1980). Magnetic Field of a Nerve Impulse: First Measurements. doi
    23. (1952). Movement of sodium and potassium ions during nervous activity. doi
    24. (1992). Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons.
    25. (1952). Propagation of electrical signals along giant nerve fibers. doi
    26. (1999). Properties of slow, cumulative sodium channel inactivation in rat hippocampal CA1 pyramidal neurons.
    27. (1990). Properties of the fast sodium channels in pyramidal neurones isolated from the CA1 and CA3 areas of the hippocampus of postnatal rats.
    28. (1962). Replacement of the axoplasm of giant nerve fibres with artificial solutions.
    29. (1961). Replacement of the protoplasm of a giant nerve fibre with artificial solutions.
    30. (2000). Resting and active properties of pyramidal neurons in subiculum and CA1 of rat hippocampus.
    31. (1838). Sur le courant electrique ou propre de la grenouille; second mémoire sur l'electricité animale, faisant suite à celui sur la torpille.
    32. (2001). Synaptic scaling in vitro and in vivo. Nature Neuroscience 4(9): 853-854. Web source: http://lobster.ls.huji.ac.il/idan/files/London_Segev_NN2001.pdf Magee,
    33. (2003). Techniques: Applications of the nervebouton preparation in neuropharmacology.
    34. (1976). Tetrodotoxin-resistant dendritic spikes in avian Purkinje cells.
    35. (1952). The components of the membrane conductance in the giant axon of the Loligo.
    36. (1952). The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.
    37. (1964). The effect of diluting the internal solution on the electrical properties of a perfused giant axon.
    38. (1962). The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons.
    39. (2002). The IUPHAR Compendium of Voltage-gated Ion Channels, doi
    40. (1972). Theoretical Electrotechnics. Volume I. Publishing house “Technics”,
    41. (1850). This and the two following references are to be soon available on Helmholtz’ multivolume Gesammelte Werke series being published by Georg Olms Verlag of Hildesheim; web source http://www.olms.de von Helmholtz,
    42. (1844). Traité des phénomènes électro-physiologiques des animaux.

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