Article thumbnail

The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?

By Jean-Baptiste Menassol, Claire Tautou, Armelle Collet, Didier Chesneau, Didier Lomet, Joëlle Dupont, Benoît Malpaux and Rex J Scaramuzzi
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2010). A language and environment for statistical computing.
  2. (1974). AJ: Melatonin inhibition of insulin secretion in the rat and mouse. Hormone Research
  3. (1973). AJ: The effect of melatonin on insulin secretion in rat and mouse.
  4. (2008). AMPK: a link between metabolism and reproduction? Med Sci (Paris)
  5. (2003). Amplitude of the plasma melatonin nycthemeral rhythms is not associated with the dates of onset and offset of the seasonal ovulatory activity in the Ile-de-France ewe. Reprod Nutr Dev
  6. (1967). Atlas stéréotaxique du cerveau de brebis pré-alpes du sud Paris: INRA;
  7. (2002). Carling D: The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.
  8. (2007). Chung JH: Activation of 5’-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.
  9. (2004). CJ: AMP-activated protein kinase plays a role in the control of food intake.
  10. (2001). DE: Role of AMP-activated protein kinase in mechanism of metformin action.
  11. (1995). DG: 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMPactivated protein kinase in intact cells?
  12. (1987). DG: A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
  13. (1998). DG: AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
  14. (2005). DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab
  15. (1983). Direct radioimmunoassay for melatonin in plasma. Clin Chem
  16. (2007). DJ: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
  17. (2007). E: Melatonin and type 2 diabetes - a possible link? J Pineal Res
  18. (2003). ER: Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett
  19. (1992). I: Seasonal changes in oestrus activity and ovulation rate in Rasa Aragonesa ewes maintained at two different body condition levels. Small Ruminant Res
  20. (1988). Karsch FJ: How does melatonin code for day length in the ewe: duration of nocturnal melatonin release or coincidence of melatonin with a light-entrained sensitive period? Biol Reprod
  21. (2006). L: 5-Aminoimidazole-4-carboxamide-1-beta-Dribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. Diabetes
  22. (1996). Maestroni GJ: Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice.
  23. (2003). Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland.
  24. (1986). MP: [Conditions for the use of specific antibodies for immunohistochemical visualization of serotonin and melatonin in the pineal gland of sheep].
  25. (2006). Mülbauer E: Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status.
  26. (1992). MV: Plasma melatonin profiles of Romney Marsh sheep in natural photoperiod and in acutely extended darkness. J Reprod Fertil
  27. (1997). Pevet P: Environmental control of the seasonal variations in the daily pattern of melatonin synthesis in the European hamster, Cricetus cricetus. Gen Comp Endocrinol
  28. (2011). PTW: Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell Signal
  29. (2003). Ribelayga C: Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev
  30. Seasonal regulation of reproduction in mammals. In Knobil and Neill’s Physiology of Reproduction. Volume 1-2.. Third edition. Edited by: Neill JD. The University of Alabama,
  31. Seasonal variations in the amplitude of the daily pattern of melatonin secretion in mammalian and non-mammalian vertebrates: Possible physiological consequences.
  32. (2003). Synchronization of the molecular clockwork by light- and food-related cues in mammals. Biol Chem
  33. (1968). The brain of the sheep. Atlas of the Brains of Domestic Animals Tokyo:
  34. (2008). The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats.
  35. (2009). Turnover rate of cerebrospinal fluid in female sheep: changes related to different light-dark cycles. Cerebrospinal Fluid Res
  36. (2010). Viollet B: Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
  37. (2002). WW: Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle.
  38. (2006). Zierath JR: AMP-activated protein kinase signaling in metabolic regulation.