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2-Amino-3,4,5,6-tetra­fluoro­benzoic acid

By Xiao-Jian Liao, Wei Guo and Shi-Hai Xu


The asymmetric unit of the title compound, C7H3F4NO2, obtained as an inter­mediate in the synthesis of a coupling reagent, contains four independent and conformationally similar mol­ecules. The amine H atoms form both intra­molecular and inter­molecular N—H⋯Ocarbox­yl hydrogen bonds which, together with inter­molecular O—H⋯Ocarbox­yl hydrogen bonds and N—H⋯F associations form ribbon structures along the a axis

Topics: Organic Papers
Publisher: International Union of Crystallography
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Provided by: PubMed Central

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  1. (2008). Comment The title compound C7H3F4NO2 (I) was obtained as one of the intermediates in the synthesis of a coupling reagent (Xu et al., 2008, Liao et al., 2007), using the Hofmann rearrangement (Perumal & Muthialu,
  2. (2010). CrysAlis PRO. Oxford Diffraction Ltd,
  3. Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) x y z Uiso*/Ueq