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Brain inflammation is induced by co-morbidities and risk factors for stroke

By Caroline Drake, Hervé Boutin, Matthew S. Jones, Adam Denes, Barry W. McColl, Johann R. Selvarajah, Sharon Hulme, Rachel F. Georgiou, Rainer Hinz, Alexander Gerhard, Andy Vail, Christian Prenant, Peter Julyan, Renaud Maroy, Gavin Brown, Alison Smigova, Karl Herholz, Michael Kassiou, David Crossman, Sheila Francis, Spencer D. Proctor, James C. Russell, Stephen J. Hopkins, Pippa J. Tyrrell, Nancy J. Rothwell and Stuart M. Allan

Abstract

► Risk factors for stroke include atherosclerosis, obesity, diabetes and hypertension. ► Stroke risk factors are associated with peripheral inflammation. ► Corpulent rats and atherogenic mice show increased inflammation in the brain. ► Pilot data show that patients at risk of stroke may also develop brain inflammation. ► Chronic peripheral inflammation can drive inflammatory changes in the brain

Topics: Article
Publisher: Academic Press
OAI identifier: oai:pubmedcentral.nih.gov:3145158
Provided by: PubMed Central
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