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Targeted Maximum Likelihood Based Causal Inference: Part II

By Mark J. van der Laan

Abstract

In this article, we provide a template for the practical implementation of the targeted maximum likelihood estimator for analyzing causal effects of multiple time point interventions, for which the methodology was developed and presented in Part I. In addition, the application of this template is demonstrated in two important estimation problems: estimation of the effect of individualized treatment rules based on marginal structural models for treatment rules, and the effect of a baseline treatment on survival in a randomized clinical trial in which the time till event is subject to right censoring

Topics: Article
Publisher: Berkeley Electronic Press
OAI identifier: oai:pubmedcentral.nih.gov:3126672
Provided by: PubMed Central
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