Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer
By Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura and Ryuji Hamamoto
(1993). A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucleic Acids Res
(1997). A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
(2003). A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples. Mol Pathol
Alexandrow MG: Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.
(2010). Anti-HER2 neoadjuvant and adjuvant therapies in HER2 positive breast cancer. Cancer Treat Rev
(2001). Bepler G: MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer.
(2010). Botchan MR: Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell
(2003). C: Molecular classification of breast carcinomas using tissue microarrays. Diagn Mol Pathol
(2007). Cancer-testis antigen lymphocyte antigen 6 complex locus K is aserologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res
(2006). Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.
(2010). Daigo Y: Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis. Clin Cancer Res
(2006). DH: Paclitaxel-carboplatin alone or with bevacizumab for nonsmall-cell lung cancer.
(2002). DM: Mammalian nuclei become licensed for DNA replication during late telophase.
(2005). DNA helicases as targets for anticancer drugs. Curr Med Chem Anticancer Agents
(2008). Gandara DR: Aurora kinases as anticancer drug targets. Clin Cancer Res
(2009). Gatzemeier U: Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet
(2006). Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer.
(2008). Gillespie PJ: Replication licensing and cancer–a fatal entanglement? Nat Rev Cancer
(2010). Grothey A: Adjuvant therapy for colon cancer: learning from the past to inform the future. Ann Surg Oncol
(2011). Hamamoto R: Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
(2005). Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays.
(2009). Individualized adjuvant chemotherapy for surgically resected lung cancer and the roles of biomarkers. Ann Thorac Cardiovasc Surg
Ishimi Y: Biochemical analysis of the intrinsic
(2009). Ito H: Expression of minichromosome maintenance 7 (MCM7) in small lung adenocarcinomas (pT1): Prognostic implication. Lung Cancer
(2004). Kabbinavar F: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
(2004). Katagiri T: Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene
(2006). Luo JH: MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene
(2010). Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol
(1999). MCM proteins in DNA replication. Annu Rev Biochem
(2002). Nuchtern JG: Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. Cancer Res
(2008). Onesti S: The MCM complex: (just) a replicative helicase? Biochem Soc Trans
(2011). Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.
(2010). Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer
(2010). Pivot X: Safety profile of new anticancer drugs. Expert Opin Drug Saf
(1995). Purification of an MCMcontaining complex as a component of the DNA replication licensing system. Nature
(1988). RA: A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature
(2005). Ratain MJ: Pharmacokinetic variability of anticancer agents. Nat Rev Cancer
(2006). Shohet JM: Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene
(2003). Song SY: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix.
(1998). The replication licensing system. Biol Chem
(1999). The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity.
(2001). Todorov IT, Bepler G: MCM2–a promising marker for premalignant lesions of the lung: a cohort study.
(2001). Tsunoda T: Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after lasercapture microdissection of tumor tissues and normal epithelia. Cancer Res
(2001). Tye BK: Initiating DNA synthesis: from recruiting to activating the MCM complex.
(2005). Y: A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res
(2004). Y: ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res
(2003). Y: Expression profiles of non-small cell lung cancers on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene
(2004). Y: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.