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Emergence of Disseminated Infections Due to Geosmithia argillacea in Patients with Chronic Granulomatous Disease Receiving Long-Term Azole Antifungal Prophylaxis▿

By Marie Machouart, Dea Garcia-Hermoso, Alexandre Rivier, Noura Hassouni, Emilie Catherinot, Alexandra Salmon, Anne Debourgogne, Hélène Coignard, Marc Lecuit, Marie-Elisabeth Bougnoux, Stéphane Blanche and Olivier Lortholary


We report two cases of invasive infections due to Geosmithia argillacea, an emerging mold, in patients with chronic granulomatous disease receiving prolonged azole antifungal prophylaxis. One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon

Topics: Case Reports
Publisher: American Society for Microbiology
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Provided by: PubMed Central
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