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Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling

By Andrej Jedinak, Shailesh Dudhgaonkar, Qing-li Wu, James Simon and Daniel Sliva
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2005). Akira S: Toll-like receptors in innate immunity. Int Immunol
  2. (2003). Alves de Lima PL, Delmanto RD, da Eira AF, Salvadori DMF, Ribeiro LR: Antimutagenic effect of Lentinula edodes(BERK.) Pegler mushroom and possible variation among lineages. Food Chem Toxicol
  3. (2008). Anti-inflammatory and analgesic properties in a rodent model of a (1–>3),(1–>6)-linked beta-glucan isolated from Pleurotus pulmonarius.
  4. (2008). Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii(Eringi),Grifola frondosa (Maitake), and Hypsizygus marmoreus(Bunashimeji) in apolipoprotein E-deficient mice. Nutr Res
  5. (2004). Araki S: Effects of intravenous infusion of highly purified vitamin B2 on lipopolysaccharide-induced shock and bacterial infection in mice.
  6. (1999). Autolysis of lentinan, an antitumor polysaccharide, during storage of Lentinus edodes shiitake mushroom. J Agric Food Chem
  7. (2009). Cantorna MT: The effects of whole mushrooms during inflammation.
  8. (2006). Cyclooxygenase-2 gene transcription in a macrophage model of inflammation.
  9. (2003). da Eira AF, Barbisan LF: Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat. Food Chem Toxicol
  10. (2008). DR: Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation.
  11. (2002). DW: Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Rev Immunol
  12. (2001). Effect of pleuran (beta-glucan from Pleurotus ostreatus) in diet or drinking fluid on colitis in rats. Nahrung
  13. (2003). Farnarier C: IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol
  14. (2003). Ho NWY: Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells.
  15. (2008). Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through
  16. (2005). Inhibitory mechanisms of highly purified vitamin B2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice. Life Sci
  17. (2008). Islam SS: Structural analysis of a polysaccharide isolated from the aqueous extract of an edible mushroom, Pleurotus sajor-caju, cultivar Black Japan. Carbohydr Res
  18. (2009). JC: Anti-inflammatory activity of aqueous and alkaline extracts from mushrooms (Agaricus blazei Murill). J Med Food
  19. (2008). JHY: 3,3’-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages.
  20. (2001). JL: Non-volatile taste components of several commercial mushrooms. Food Chemistry
  21. (1996). Jr: The NF-kappa B and I kappa B proteins new discoveries and insights. Annu Rev Immunol
  22. (2004). KK: Methanol extract of the oyster mushroom,Pleurotus florida, inhibits inflammation and platelet aggregation. Phytother Res
  23. (1995). KM: Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol
  24. (2009). L: STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 Jedinak et al.
  25. (2002). Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol
  26. (2007). Meydani SN: Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice.
  27. (2008). Meyers FJ Gershwin ME: The immunobiology of mushrooms. Exp Biol Med (Maywood)
  28. (2007). MR: AP-1 a target for cancer prevention. Curr Cancer Drug Targets
  29. (2008). Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro. Biochem Biophys Res Commun
  30. (2002). New sterols from two edible mushrooms, Pleurotus eryngii and Panellus serotinus. Chem Pharm Bull (Tokyo)
  31. (1984). NK: Anti-inflammatory and analgesic properties of four amino-acids.
  32. (2001). Piironen V: Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. J Agric Food Chem
  33. (2008). Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway.
  34. (2008). Pleurotus ostreatus,a n oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. Chem Biol Interact
  35. (2001). Plevy SE: Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach.
  36. (2001). Ribeiro LR: Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat Res
  37. (1995). RP: The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA
  38. (2005). Savelkoul HFJ: Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm
  39. (2005). SP: Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol
  40. (2009). Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int Immunopharmacol
  41. (1999). TS: Chloromethyl ketones inhibit interleukin-12 production in mouse macrophages stimulated with lipopolysaccharide. Immunol Lett
  42. (2000). TS: Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.
  43. (2006). Tweddell RJ: A bioactive (1–>3)-, (1–4)-beta-D-glucan from Collybia dryophila and other mushrooms. Mycologia
  44. (2000). Ulevitch RJ: Toll-like receptors in the induction of the innate immune response. Nature
  45. (2007). Vogel SN: Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
  46. (2008). White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice.
  47. (2006). Wild-gathered fungi for health and rural livelihoods. Proc Nutr Soc
  48. (2003). YM: Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull