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Varicocele-induced infertility: Newer insights into its pathophysiology

By Michael L. Eisenberg and Larry I. Lipshultz

Abstract

The association between varicoceles and male infertility has been known since the 1950s; however, the pathophysiology of the process remains uncertain. The primary proposed hypotheses involve hyperthermia, venous pressure, testicular blood flow, hormonal imbalance, toxic substances, and reactive oxygen species. It is difficult to identify a single or dominant factor, and it is likely that many of these factors contribute to the infertile phenotype seen in clinical practice. Moreover, patient lifestyle and genetic factors likely affect patient susceptibilities to the varicocele insult. While the current studies have weaknesses, they provide building blocks for futures studies into the pathophysiology of the varicocele

Topics: Symposium
Publisher: Medknow Publications
OAI identifier: oai:pubmedcentral.nih.gov:3114589
Provided by: PubMed Central
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