Article thumbnail

Statement on guidance for genetic counseling in advanced paternal age

By Helga V. Toriello and Jeanne M. Meck


In 1996, a practice guideline on genetic counseling for advanced paternal age was published. The current document updates the state of knowledge of advanced paternal age effects on single gene mutations, chromosome anomalies, and complex traits

Topics: ACMG Practice Guidelines
Publisher: Lippincott, Williams & Wilkins
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. ACMG Professional Practice and Guidelines Committee. First trimester diagnosis and screening for fetal aneuploidy.
  2. Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population.
  3. Advancing paternal age and the risk of schizophrenia.
  4. (2006). Age and sex effects on human mutation rates: an old problem with new complexities.
  5. Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors.
  6. Are children of older fathers at risk for genetic disorders? Andrologia 2003;35:191–199.
  7. Association of early life factors and acute lymphoblastic leukaemia in childhood: historical cohort study.
  8. Association of paternal age at birth and the risk of breast cancer in offspring: a case control study.
  9. (1997). BuninGR,NeedleM,RiccardiVM.Paternalageandsporadicneurofibromatosis1: a case-control study and consideration of the methodologic issues. Genet Epidemiol
  10. ByrneM,AgerboE,EwaldH,EatonWW,etal.Parentalageandriskofschizophrenia: a case-control study.
  11. (2007). CantorRM,YoonJL,FurrJ,LajonchereCM.Paternalageandautismareassociated in a family-based sample. Mol Psychiatr
  12. Case-control study of parental age,parityandsocioeconomiclevelinrelationtochildhoodcancers.IntJEpidemiol
  13. (2004). Clinical management guidelines for obstetrician-gynecologists. Ultrasonography in pregnancy.
  14. (2007). CroenLA,NajjarDV,FiremanB,GretherJK.Maternalandpaternalageandriskof autism spectrum disorders. Arch Pediatr Adolesc Med
  15. (2004). Dear old dad. Sci Aging Knowledge Environ
  16. DeLaRochebrochardE,ThonneauP.Paternalageor40years:animportantrisk factor for infertility.
  17. (1995). Effect of paternal age in achondroplasia, thanatophoric dysplasia, and osteogenesis imperfecta.
  18. (2001). Effect of paternal age on human sperm chromosomes. Fertil Steril
  19. Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa.
  20. (1981). Genetic disease in the offspring of older fathers. Obstet Gynecol
  21. HookEB.Paternalageandeffectsonchromosomalandspecificlocusmutationsand on other genetic outcomes in offspring.
  22. LoweX,EskenaziB,NelsonDO,KiddS,etal.FrequencyofXYspermincreaseswith age in fathers of boys with Klinefelter syndrome.
  23. (1996). MollAC,ImhofSM,KuikDJ,BouterLM,etal.Highparentalageisassociatedwith sporadic hereditary retinoblastoma: the Dutch retinoblastoma register 1862–1994. Hum Genet
  24. Parental age and risk of childhood cancers: a population-based cohort study from Sweden.
  25. Parental age at child’s birth and son’s risk of prostate cancer. The Framingham study.
  26. (2005). Parental age at delivery, birth order, birth weightandgestationalageareassociatedwiththeriskofchildhoodType1diabetes: a UK regional retrospective cohort study. Diabet Med
  27. (1990). Parental age in sporadic hereditary retinoblastoma.
  28. Parental age, family size, and risk of multiple sclerosis.
  29. (2007). Paternal age and birth defects: how strong is the association? Hum Reprod
  30. (2005). Paternal age and congenital malformations. Hum Reprod
  31. Paternal age and epilepsy in the offspring.
  32. Paternal age and preeclampsia.
  33. Paternal age and schizophrenia: further support for an association.
  34. (1986). Paternal age and the occurrence of birth defects.
  35. (1994). Paternal age and the risk of congenital heart defects.
  36. Paternal age as a risk factor for low birthweight.
  37. (2006). Paternal age, size at birth, and size in young adulthood—risk factors for schizophrenia.
  38. (2004). Reproductive functions of the ageing male. Hum Reprod Update
  39. (1986). Risk of dominant mutation in older fathers: evidence from osteogenesis imperfecta.
  40. (2007). Screening for fetal chromosomal abnormalities.
  41. SlamaR,BouyerJ,WindhamG,FensterL,etal.Influenceofpaternalageontherisk of spontaneous abortion.
  42. SplendoreA,JabsEW,FelixTM,Passos-BuenoMR.Parentaloriginofmutationsin sporadic cases of Treacher Collins syndrome.
  43. (1987). Spontaneous mutation and parental age in humans.
  44. The high spontaneous mutation rate: is it a health risk?
  45. The influence of paternal age on Down syndrome.
  46. The observed human sperm mutationfrequencycannotexplaintheachondroplasiapaternalageeffect.ProcNatl Acad SciUSA2002;99:14952–14957.