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Adherence with Preventive Medication in Childhood Asthma

By Scott Burgess, Peter Sly and Sunalene Devadason


Suboptimal adherence with preventive medication is common and often unrecognised as a cause of poor asthma control. A number of risk factors for nonadherence have emerged from well-conducted studies. Unfortunately, patient report a physician's estimation of adherence and knowledge of these risk factors may not assist in determining whether non-adherence is a significant factor. Electronic monitoring devices are likely to be more frequently used to remind patients to take medication, as a strategy to motivate patients to maintain adherence, and a tool to evaluate adherence in subjects with poor disease control. The aim of this paper is to review non-adherence with preventive medication in childhood asthma, its impact on asthma control, methods of evaluating non-adherence, risk factors for suboptimal adherence, and strategies to enhance adherence

Topics: Review Article
Publisher: Hindawi Publishing Corporation
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Provided by: PubMed Central

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  1. (1992). A comparison of the effects of bid and qid dosing on compliance with inhaled flunisolide,”
  2. (1991). A nebulizer chronolog to monitor compliance with inhaler use,”
  3. (2003). Adherence intervention research: what have we learned and what do we do next?”
  4. (2002). Adherence to asthma therapy in the preschool child,”
  5. (2007). Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trial,”
  6. (1998). Adherence with twice-daily dosing of inhaled steroids: socioeconomic and health-belief differences,”
  7. (1998). Adolescents’ perceptions of physicians, nurses, parents and friends: help or hindrance in compliance with diabetes self-care?”
  8. (2007). An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma,”
  9. (1992). An evaluation of severity-modulated compliance with q.i.d. dosing of inhaled beclomethasone,”
  10. (2008). Assessing adherence and factors associated with adherence in young children with asthma,” Respirology,v o l .1 3 ,n o .4 ,p p .
  11. (1987). Asthma deaths in childhood: identification of patients at risk and intervention,”
  12. (1996). Asthma management by preschool children and their families: a developmental framework,”
  13. (1995). B o s l e y ,J .A .F o s b u r y ,a n dG .M .C o c h r a n e ,“ T h e psychological factors associated with poor compliance with treatment in asthma,”
  14. (2000). Barriers to asthmacareinurbanchildren:parentperspectives,”Pediatrics,
  15. (2001). Behavioral adjustment in children with asthma: a meta-analysis,”
  16. (2003). Caregiver-physician medication concordance and undertreatment of asthma among inner-city children,”
  17. (1983). Clinicians’ assessments of children’s understanding of illness,”
  18. (1986). Compliance of patients with asthma with an experimental aerosolized medication: implications for controlled clinical trials,”
  19. Compliance with an oral asthma medication: a pilot study using an electronic monitoring device,”RespiratoryMedicine,vol.94,no.9,pp.852–858,2000.
  20. (1995). Compliance with inhaled asthma medication in preschool children,”
  21. (1996). Compliance with nedocromil sodium and a nedocromil sodium/ salbutamol combination,”
  22. (2006). Compliance, adherence, and concordance: implications for asthma treatment,”
  23. (1986). Controlled evaluation of the effects of patient education on asthma morbidity in general practice,”
  24. (2001). Corticosteroid prescription filling for children covered by Medicaid following an emergency department visit or a hospitalization for asthma,”
  25. (2000). Defining the margins for errors in patient compliance with prescribed drug regimens,”
  26. (1977). Diagnosing potential noncompliance. Physicians’ ability in a behavioral dimension of medical care,”
  27. (2003). Direct clinician-topatient feedback discussion of inhaled steroid use: its effect on
  28. Diskus and diskhaler: efficacy and safety of fluticasone propionate via two dry powder inhalers in subjects with mild-to-moderate persistent asthma,”
  29. (2002). Drug compliance in adolescents: assessing and managing modifiable risk factors,” Pediatric Drugs,
  30. (2004). Drug delivery and adherence in young children,”
  31. (2002). Electronic monitoring of medication adherence: when is high-tech best?”
  32. (2002). Enhancing medication adherence among inner-city children with asthma: results from pilot studies,”
  33. (1996). Enhancing patient compliance in pediatrics,”
  34. (1993). Feedback on medication dosing enhances patient compliance,”
  35. (2004). G.Chaney,B.Clements,L.Landau,M.Bulsara,andP.Watt,“A new asthma spacer device to improve compliance in children: a pilot study,”
  36. (2001). h e r m a n ,P .P a t e l ,A .H u t s o n ,S .C h e s r o wn ,a n dL .H e n d e l e s , “Adherence to oral montelukast and inhaled fluticasone in children with persistent asthma,”
  37. (1996). i l g r o m ,B .B e n d e r ,L .A c k e r s o n ,P .B o w r y ,B .S m i t h ,a n d C. Rand, “Noncompliance and treatment failure in children with asthma,”
  38. (1993). Improving inhaler adherence in a clinical trial through the use of the nebulizer chronolog,”
  39. (2007). Inhaled corticosteroids for asthma,”
  40. (1989). Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications,”
  41. (1986). J ones,andJ .R.S ibert,“T wic edailyv ersus four times daily treatment with beclomethasone dipropionate in the control of mild childhood asthma,”
  42. (2004). Maternal depressive symptoms and adherence to therapy in inner-city children with asthma,”
  43. (2000). Measurement of children’s asthma medication adherence by self report, mother report, canister weight,
  44. (2004). Measuring adherence with the Doser CT in children with asthma,”
  45. (2003). Medication adherence in pediatric asthma: reasoning, responsibility, and behavior,”
  46. (2004). Medication non-adherence and asthma treatment cost,”
  47. (1995). Microelectronic systems for monitoring and enhancing patient compliance with medication regimens,”
  48. (2008). Negative affect, medication adherence, and asthma control in children,”
  49. (2000). Non-compliance amongst adolescents with asthma: listening to what they tell us about self-management,” Family Practice,
  50. (1993). Non-compliance or rational decision,”
  51. (2007). Novel spacer device does not improve adherence in childhood asthma,”
  52. (1992). P .C o u t t s ,N .A .G i b s o n ,a n dJ .Y .P a t o n ,“ M e a s u r i n g compliance with inhaled medication
  53. (1996). P.Tashkin,“Trendsincompliancewithbronchodilatorinhaler use between follow-up visits in a clinical trial,”
  54. (1999). Patient compliance in a clinical trial with inhaled budesonide in children with mild asthma,”
  55. (1992). Pediatric asthma deaths in Victoria: the mild are at risk,” Pediatric pulmonology,
  56. (2008). Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help?”
  57. (1980). Predicting compliance with a regimen of digoxin therapy in family practice,”
  58. (1998). Preventable factors in hospital admissions for asthma,”
  59. (2010). Providing feedback on adherence increases use of preventive medication by asthmatic children,”
  60. (1998). Psychological factors associated with medication nonadherence in asthmatic children,”
  61. (1989). Psychosocial aspects of compliance in children and adolescents with asthma,”
  62. (2002). r v i n e ,I .K .C r o m b i e
  63. (1993). Rapoff,a n d
  64. (2003). Relations among asthma knowledge, treatment adherence, and outcome,”
  65. (2004). Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma,”
  66. (1998). Schork et al., “Impact of education for physicians on patient outcomes,”
  67. (1998). Single centre open study to compare patient recording of PRN salbutamol use on a daily diary card with actual use as recorded by the MDI compliance monitor,”
  68. (1996). Social desirability, perceived stress, and PACT ratings in lung transplant candidates: a preliminary investigation,”
  69. (2005). Stoloff,J .R .C .R o s e n z w e i g
  70. (2004). Stoloff,M .A .S t e m p e l ,J .M e y e r ,R .H .S t a n f o r d ,a n d
  71. (2000). The allocation of familyresponsibilityforasthmamanagementtasksinAfricanAmerican adolescents,”
  72. (1989). The relationship between knowledge and reported behavior in childhood asthma,”
  73. (1985). The value of participating in an asthma trial,”
  74. (1998). Treatment adherence among low-income children with asthma,”
  75. (2000). Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in a clinical trial,”
  76. (2002). W o o d ,L .A .S m i t h ,D .R o m e r o ,P .B r a d s h a w ,P .H .W i s e
  77. (1993). When tubercolosis treatment fails: a social behavioral account of patient adherence,”
  78. (2004). Why Don’t children take their asthma medications? A qualitative analysis of children’s perspectives on adherence,”