Article thumbnail

Mitochondrial DNA Damage and Repair in RPE Associated with Aging and Age-Related Macular Degeneration

By Haijiang Lin, Haifeng Xu, Fong-Qi Liang, Hao Liang, Praveena Gupta, Anna N. Havey, Michael E. Boulton and Bernard F. Godley


The authors show that macular-specific increases in mtDNA damage, heteroplasmic mutations, and diminished repair are associated with aging and with severity of age-related macular degeneration (AMD). Additionally, they link the accumulation of mtDNA damage to a decline in expression of the DNA repair enzyme OGG1 and speculate that this decline contributes to inefficient DNA repair capacity, especially in eyes with more advanced AMD

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles