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Mitochondrial DNA Damage and Repair in RPE Associated with Aging and Age-Related Macular Degeneration

By Haijiang Lin, Haifeng Xu, Fong-Qi Liang, Hao Liang, Praveena Gupta, Anna N. Havey, Michael E. Boulton and Bernard F. Godley

Abstract

The authors show that macular-specific increases in mtDNA damage, heteroplasmic mutations, and diminished repair are associated with aging and with severity of age-related macular degeneration (AMD). Additionally, they link the accumulation of mtDNA damage to a decline in expression of the DNA repair enzyme OGG1 and speculate that this decline contributes to inefficient DNA repair capacity, especially in eyes with more advanced AMD

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3109040
Provided by: PubMed Central
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