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Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study

By Mika Kivimäki, Costan G Magnussen, Markus Juonala, Mika Kähönen, Johannes Kettunen, Britt-Marie Loo, Terho Lehtimäki, Jorma Viikari and Olli T Raitakari


Background Lipoprotein(a) [Lp(a)] is an established risk factor for coronary disease and stroke, but mechanisms underlying this association are unknown. We examined the association of Lp(a) with early atherosclerosis by using conventional epidemiologic analysis and a Mendelian randomization analysis. The latter utilized genetic variants that are associated with Lp(a) to estimate causal effect

Topics: Genetic Epidemiology
Publisher: Oxford University Press
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Provided by: PubMed Central
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