Article thumbnail

Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study

By Mika Kivimäki, Costan G Magnussen, Markus Juonala, Mika Kähönen, Johannes Kettunen, Britt-Marie Loo, Terho Lehtimäki, Jorma Viikari and Olli T Raitakari

Abstract

Background Lipoprotein(a) [Lp(a)] is an established risk factor for coronary disease and stroke, but mechanisms underlying this association are unknown. We examined the association of Lp(a) with early atherosclerosis by using conventional epidemiologic analysis and a Mendelian randomization analysis. The latter utilized genetic variants that are associated with Lp(a) to estimate causal effect

Topics: Genetic Epidemiology
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3106966
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles