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Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α

By Karsten H. Weylandt, Lena F. Krause, Beate Gomolka, Cheng-Ying Chiu, Süleyman Bilal, Anja Nadolny, Simon F. Waechter, Andreas Fischer, Michael Rothe and Jing X. Kang

Abstract

Liver tumors, particularly hepatocellular carcinoma (HCC), are a major cause of morbidity and mortality worldwide. The development of HCC is mostly associated with chronic inflammatory liver disease of various etiologies. Previous studies have shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) dampen inflammation in the liver and decrease formation of tumor necrosis factor (TNF)-α

Topics: Cancer Prevention
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3106436
Provided by: PubMed Central
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