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Asymmetric HIV-1 co-receptor use and replication in CD4+ T lymphocytes

By Samanta A Mariani, Elisa Vicenzi and Guido Poli

Abstract

Susceptibility to infection by the human immunodeficiency virus type-1 (HIV-1), both in vitro and in vivo, requires the interaction between its envelope (Env) glycoprotein gp120 Env and the primary receptor (R), CD4, and Co-R, either CCR5 or CXCR4, members of the chemokine receptor family. CCR5-dependent (R5) viruses are responsible for both inter-individual transmission and for sustaining the viral pandemics, while CXCR4-using viruses, usually dualtropic R5X4, emerge in ca. 50% of individuals only in the late, immunologically suppressed stage of disease. The hypothesis that such a major biological asymmetry is explained exclusively by the availability of cells expressing CCR5 or CXCR4 is challenged by several evidences. In this regard, binding of the HIV-1 gp120 Env to the entry R complex, i.e. CD4 and a chemokine R, leads to two major events: virion-cell membrane fusion and a cascade of cell signaling. While the fusion/entry process has been well defined, the role of R/Co-R signaling in the HIV-1 life cycle has been less characterized. Indeed, depending on the cellular model studied, the capacity of HIV-1 to trigger a flow of events favoring either its own latency or replication remains a debated issue. In this article, we will review the major findings related to the role of HIV R/Co-R signaling in the steps following viral entry and leading to viral spreading in CD4+ T lymphocytes

Topics: Review
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3105508
Provided by: PubMed Central

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Citations

  1. (1998). al: 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP3beta receptor CCR7.
  2. (1996). al: A dualtropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell
  3. (1992). al: Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.
  4. (2009). al: Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance.
  5. (1998). al: Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-gamma of fusin/CXCR4.
  6. (1999). al: Envelope-dependent restriction of human immunodeficiency virus type 1 spreading in CD4(+) T lymphocytes: R5 but not X4 viruses replicate in the absence of T-cell receptor restimulation.
  7. (1989). al: Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.
  8. al: HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.
  9. (2010). al: R5 and X4 HIV envelopes induce distinct gene expression profiles in Mariani et al.
  10. (1990). AS: Direct and cytokinemediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells.
  11. (2005). Bacterial toxins: potential weapons against HIV infection. Curr Pharm Des
  12. CH: Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation.
  13. CH: Naive and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.
  14. Corbeau P: Pairwise comparison of isogenic HIV-1 viruses: R5 phenotype replicates more efficiently than X4 phenotype in primary CD4+ T cells expressing physiological levels of CXCR4.
  15. (1998). CR: Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today
  16. (1997). CR: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
  17. (1998). Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity
  18. (1998). DD: CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines.
  19. (2006). Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression.
  20. (1999). Doms RW: Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
  21. (2006). E, et al: HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells. Virology
  22. (1996). EA: CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science
  23. (1996). EA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science
  24. (1998). Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J Virol
  25. (1994). et al: Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science
  26. (2005). et al: Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.
  27. (1996). et al: Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation.
  28. (2000). et al: CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes.
  29. (1997). et al: Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells. Science
  30. (1997). et al: Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.
  31. (2002). et al: HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.
  32. (2008). et al: HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell
  33. (2002). et al: HIV preferentially infects HIV-specific CD4+ T cells. Nature
  34. (2001). et al: HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues. Immunity
  35. (1997). et al: HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.
  36. (2007). et al: HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS
  37. (1996). et al: Identification of a major co-receptor for primary isolates of HIV-1. Nature
  38. (1998). et al: IL-4 induces functional cell-surface expression of CXCR4 on human T cells.
  39. (1999). et al: Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope.
  40. (2000). et al: Limited expression of R5-tropic HIV-1 in CCR5-positive type 1-polarized T cells explained by their ability to produce RANTES, MIP-1alpha, and MIP1beta. Blood
  41. (1997). et al: Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature
  42. et al: Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection. JI m m u n o l2010,
  43. (1992). et al: Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev
  44. (2009). et al: Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state. PLoS Pathog
  45. (1997). et al: Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med
  46. (2010). et al: Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.
  47. (1984). et al: T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature
  48. (1996). et al: The betachemokine receptors CCR3 and CCR5 facilitate infection by primary HIV1 isolates. Cell
  49. (1996). et al: The CXC chemokine SDF-1 is the ligand for LESTR/ fusin and prevents infection by T-cell-line-adapted HIV-1. Nature
  50. (1986). et al: The T4 glycoprotein is a cell-surface receptor for the AIDS virus. Cold Spring Harb Symp Quant Biol
  51. (1995). Fauci AS: HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/ paracrine manner by endogenous cytokines.
  52. (2003). G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates.
  53. (2005). G-protein signaling triggered by R5 human immunodeficiency virus type 1 increases virus replication efficiency in primary T lymphocytes.
  54. (1993). Geballe AP: Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line.
  55. (1993). GM: A TH1–>TH2 switch is a critical step in the etiology of HIV infection. Immunol Today
  56. (1989). Gonzalez-Scarano F: CD4-independent infection of human neural cells by human immunodeficiency virus type 1. J Virol
  57. (2003). HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis.
  58. (1999). Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation. Biochem Biophys Res Commun
  59. (1998). Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells.
  60. (1996). Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.
  61. JM: Th17 and regulatory T cells: implications for AIDS pathogenesis.
  62. (2004). Lanzavecchia A: Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol
  63. (1998). Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
  64. (1999). LB: CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue. Nat Med
  65. (2005). Lever AM: Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction. Retrovirology
  66. (2010). Lisco A: HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal Immunol
  67. (1996). Lusso P: The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med
  68. (1999). M: CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell
  69. (1991). Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.
  70. (1998). Pitha PM: Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.
  71. (1997). Productive and lytic infection of human CD4+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1. J Virol
  72. (1984). RA: The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature
  73. RR: Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control.
  74. Sekaly RP:
  75. (1991). Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus. Virology
  76. (1999). The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. J Exp Med
  77. (1993). The thymus and T-cell tolerance.
  78. (2008). Uittenbogaart CH: The role of the thymus in HIV infection: a 10 year perspective. AIDS