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Refractory Hypertension and Isosexual Pseudoprecocious Puberty Associated with Renin-Secreting Ovarian Steroid Cell Tumor in a Girl

By Sun Hee Lee, Mi Seon Kang, Gyeong Sin Lee and Woo Yeong Chung


Steroid cell tumor, not otherwise specified (NOS), are rare ovarian tumor, in addition, it is more rare in children. The majority of these tumors produce several steroid hormones, particularly testosterone. Estrogen also secreted by steroid cell tumor, NOS, but it is uncommon. Furthermore, hypertension is an infrequent sign in steroid cell tumor, NOS. An 8.5-yr-old girl with hypertension and frequent vaginal spotting visited at our clinic. On laboratory evaluation, secondary hypertension due to an elevated plasma renin level and isosexual pseudoprecocious puberty was diagnosed. Right solid ovarian mass was detected in radiologic tests. She underwent a right ooporectomy and it revealed renin and progesterone receptor positive steroid cell tumor, NOS. After operation, her blood pressure returned to normal level and vaginal bleeding disappeared. Even though this case is very rare, when hypertension coincides with virilization or feminization, a renin-secreting ovarian steroid cell tumor, NOS, should be considered

Topics: Case Report
Publisher: The Korean Academy of Medical Sciences
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Provided by: PubMed Central

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  1. (1963). Aldosteronism and precocious puberty due to an ovarian androblastoma (sertoli cell tumor).
  2. (2007). An ovarian steroid cell tumor causing virilization and massive ascites. Yonsei Med J
  3. (2005). Arterial hypertension and ovarian tumour in a girl: what is the link? Nephrol Dial Transplant
  4. (1979). Congenital mesoblastic nephroma presenting with primary reninism.
  5. (1989). Extrarenal renin-secreting tumors: insights into hypertension and ovarian renin production. Medicine (Baltimore)
  6. (1987). Immunohistochemical localization of renin in renal tumors.
  7. (2000). Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor.
  8. (1987). Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases.
  9. (1999). Ovarian steroid cell tumors, not otherwise specified: a case report and literature review. Gynecol Oncol
  10. (2009). Peripheral precocious puberty: causes and current management. Horm Res
  11. (1999). Physiopathology of the renin-angiotensin system in the ovary. Minerva Endocrinol
  12. (1972). Primary reninism, hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. Arch Intern Med
  13. (1991). Steroid cell tumor of the ovary in a child. Arch Pathol Lab Med
  14. (1991). Steroid hormone-producing tumors of the adrenal, ovary, and testes. Endocrinol Metab Clin North Am