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KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription

By Liangqi Xie, Carl Pelz, Wensi Wang, Amir Bashar, Olga Varlamova, Sean Shadle and Soren Impey

Abstract

Embryonic stem cell pluripotency depends on their epigenetic state, however, the pathways downstream of pluripotency factors remain unclear. Here, the Nanog target KDM5B, an H3K4me3 histone demethylase, is recruited to and activates genes involved in self-renewal, in part by facilitating transcriptional elongation by repressing cryptic transcripts

Topics: Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:3102288
Provided by: PubMed Central
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