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Targeting breast cancer stem cells: fishing season open!

By Christophe Ginestier, Emmanuelle Charafe-Jauffret and Daniel Birnbaum

Abstract

Studies describing the tumor as a hierarchically organized cell population have changed the classical oncogenesis view and propose new therapeutic strategies. Cancer stem cells (CSCs) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cancer cure. A large research effort is now aiming to develop drugs targeting CSCs, based either on a priori understanding of key pathways regulating CSC biology or on high-throughput screening to identify novel targets and compounds

Topics: Viewpoint
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3096955
Provided by: PubMed Central

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Citations

  1. (2009). Association of breast cancer stem cells identifi ed by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers. Clin Cancer Res
  2. (2008). Chang JC: Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.
  3. (2009). ES: Identifi cation of selective inhibitors of cancer stem cells by high-throughput screening. Cell
  4. Evaluating therapeutic effi cacy against cancer stem cells: new challenges posed by a new paradigm. Cell Stem Cell 2007, 1:497-501. doi:10.1186/bcr2636 Cite this article as: Ginestier C, et al.: Targeting breast cancer stem cells: fi shing season open!
  5. (2009). Glioma stem cell lines expanded in adherent culture have tumor-specifi c phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell
  6. (2008). Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer
  7. (2010). Mammosphere-forming cells from breast cancer cell lines as a tool for the identifi cation of CSC-like- and early progenitor-targeting drugs. Cell Cycle
  8. (2007). PB: Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol
  9. (2010). PG: An RNAi screen identifi es TRRAP as a regulator of brain tumor-initiating cell diff erentiation. Cell Stem Cell
  10. (2010). Wicha MS: Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in infl ammatory breast cancer. Clin Cancer Res
  11. (2009). Wicha MS: Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res
  12. (2008). Wicha MS: Cancer stem cells in breast: current opinion and future challenges. Pathobiology
  13. (2010). Wicha MS: CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
  14. (2010). Wicha MS: Targeting breast cancer stem cells.