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Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells

By Sheng-Chun Chiu, Mei-Jen Wang, Hsueh-Hui Yang, Shee-Ping Chen, Sung-Ying Huang, Yi-Lin Chen, Shinn-Zong Lin, Horng-Jyh Harn and Cheng-Yoong Pang
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1999). 12Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
  2. (2005). Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis
  3. (2003). AM: Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol Pharmacol
  4. (2007). BK: Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist
  5. (2006). CH: NSAID activated gene (NAG-1), a modulator of tumorigenesis.
  6. (2005). Chambers TC: Characterization of vinblastine-induced BclxL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction. Oncogene
  7. (1998). DD: Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
  8. (2009). Eling TE: A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett
  9. (2005). Eling TE: Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol Pharmacol
  10. (2001). Eling TE: Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol
  11. (2005). Eling TE: Protein kinase C-dependent regulation of NAG-1/ placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells.
  12. (2003). Fornace AJ Jr: Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol
  13. (2003). GM: Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci USA
  14. (2006). Harn HJ: In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells. Biochem Pharmacol
  15. (2003). HJ: Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci
  16. (2005). HJ: Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Lett
  17. (2005). HJ: Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation. Life Sci
  18. (1979). Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature
  19. (1998). I: The cdc25B phosphatase is essential for the G2/M phase transition in human cells.
  20. (1993). Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res
  21. (1999). Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med
  22. (2006). Orr GA: Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci USA
  23. (2006). SJ: A novel peroxisome proliferatoractivated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther
  24. (2005). SJ: Indole-3-carbinol and 3,3’-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun
  25. (2003). SK: Dysregulated expression of MIC-1/PDF in human prostate tumor cells. Biochem Biophys Res Commun
  26. (1986). Stereoselective reactions. XII. Synthesis of antitumor-active steganacin analogs, picrosteganol and epipicrosteganol, by selective isomerization. Chem Pharm Bull (Tokyo)
  27. Sun YH: Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.
  28. (2005). Teng CM: Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis
  29. (1989). Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature