Article thumbnail

A Chinese Herbal Medicine, Tokishakuyakusan, Reduces the Worsening of Impairments and Independence after Stroke: A 1-Year Randomized, Controlled Trial

By Hirozo Goto, Nobuhiko Satoh, Yoshinori Hayashi, Hiroaki Hikiami, Yutaka Nagata, Ryosuke Obi and Yutaka Shimada

Abstract

In post-stroke patients, the recurrence of stroke and progression of impairments lead to a bedridden state and dementia. As for their treatments, only anti-hypertension and anti-coagulation therapies to prevent the recurrence of stroke are available. In Asia, post-stroke patients with impairments are often treated with herbal medicine. The present study evaluated the effectiveness of tokishakuyakusan (TS) in improving the impairment and independence in post-stroke patients. Thirty-one post-stroke patients (mean age = 81.4 years) were recruited and enrolled. Participants were randomly assigned to the TS group (n = 16) or non-treatment (control) group (n = 15) and treated for 12 months. Impairments were assessed using the Stroke Impairment Assessment Set (SIAS). Independence was evaluated using the functional independence measure (FIM). For each outcome measure, mean change was calculated every 3 months. The results were that impairments according to SIAS did not significantly change in the TS group. In contrast, SIAS significantly worsened in the control group. There was a significant difference between the two groups. In each term of SIAS, affected lower extremity scores, abdominal muscle strength, function of visuospatial perception, and so forth. in the TS group were better than those in the control group. Independence according to FIM did not change significantly in the TS group. In contrast, FIM significantly worsened in the control group. There was also a significant difference between the two groups. In conclusion, TS was considered to suppress the impairments of lower limbs and to exert a favorable effect on cerebral function for post-stroke patients

Topics: Original Article
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3095247
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2007). A .K a w a m u r a ,M .I a c o v i d o u ,A .T a k a o k a ,C .E .S o l l ,a n d
  2. (2007). a m a s ,A .C o u r b o n ,F .R o c h e ,F .B e t h o u x ,a n dP .C a l m e l s , “Effect of training programs and exercise in adult stroke patients: literature review,” Annales de Readaptation et de Medecine Physique,
  3. (2003). A novel anti-dysmenorrhea therapy with cyclic administrationoftwoJapaneseherbalmedicines,”Clinicaland Experimental Obstetrics and Gynecology,
  4. (2002). A traditional Chinese herbal medicine, banxia houpo tang, improves cough reflex of patients with aspiration pneumonia,”
  5. (2005). Akiyoshi et al., “Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons,”
  6. (1993). An overview of Kampo medicine: Toki-Shakuyaku-San
  7. (2005). Antioxidant and antiplatelet effects of DangGui-Shao-Yao-San on human blood cells,”
  8. (2003). Antispastic effect of electroacupuncture and moxibustion in stroke patients,”
  9. (2007). Cerebral atrophy in Parkinson’s disease patients with visual hallucinations,”
  10. Choto-san in the treatment of vascular dementia: a double-blind,
  11. (2004). Effe c to fT o k i -shakuyaku-san on microcirculation of bulbar conjunctiva and hemorheological factors in patients with asymptomatic cerebral infarction,”
  12. (2007). Effect of kihito extract granules on cognitive function in patients with Alzheimer’s-type dementia,”
  13. (1994). Effect of TokiShakuyaku-San (TJ-23) on the activity of choline acetyltransferase in the brain of menopausal rats,”
  14. (2007). Effect of traditional Japanese herbal medicine tokishakuyaku-san for mild cognitive impairment:
  15. (2008). Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia,”
  16. (2004). Effects of acupuncture treatment on poststroke motor recovery and physical function: a pilot study,”
  17. (2007). Effects of exercise training programs on walking competency after stroke: a systematic review,”
  18. (1994). Functional Assessment Research Uniform Data System for Medical Rehabilitation for USD Data Management Service: Guide for Use of the Uniform Data Set for Medical Rehabilitation Including the Functional Independence Measure (FIM), UB Foundation Activities,
  19. (1993). How far is drug therapy possible for Alzheimer type dementia?”
  20. (2005). improves cognitive function and activities of daily living of patients with dementia: a double-blind, randomized, placebo-controlled study,”
  21. (1999). M.Liu,T.Tsuji,K.Tsujiuchi,andN.Chino,“Comorbiditiesin strokepatientsasassessedwithanewlydevelopedcomorbidity scale,”
  22. (1989). Measurements of acute cerebral infarction: a clinical examination scale,”
  23. (2007). Meta-analysis of traditional Chinese patent medicine for ischemic stroke,”
  24. (1997). N.Kotani,T.Oyama,I.Sakaietal.,“Analgesiceffectofaherbal medicine for treatment of primary dysmenorrheal - a doubleblind study,”
  25. (2007). Neuroprotective effects of TJ-23 (Tokishakuyakusan) on adult rat motoneurons following peripheral facial nerve axotomy,”
  26. (2006). Quality of life in patients treated with Kampo medicine: a complementary alternative to modern medicine,”
  27. (2004). S.Choetal.,“Arandomized,double-blind,placebo-controlled trial of the Chinese herbal medicine “Ba Wei Di Huang Wan” in the treatment of dementia,” J o u r n a lo ft h eA m e r i c a n Geriatrics Society,
  28. (2004). S.Yamaguchi,M.Matsubara,andS.Kobayashi,“Event-related brain potential changes after Choto-san administration in stroke patients with mild cognitive impairments,”
  29. (2002). Seijo-bofuto, Jumi-haidoku-to and Toki-shakuyaku-san suppress rashes and incidental symptoms in acne patients,”
  30. (1995). Stroke impairment assessment set (SIAS),”
  31. (1990). Task Force on Stroke Impairment, Task Force on Stroke Disability, and Task Force on Stroke Handicap, Symposium recommendations for methodology in stroke outcome research,”
  32. (1989). The Canadian neurological scale: validation and reliability assessment,”
  33. The improvement of luteal insufficiency in fecund women by Tokishakuyakusantreatment,”AmericanJournalofChineseMedicine,vol.
  34. (2004). Treatment of climacteric symptoms with herbal formulas of traditional