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Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system

By Tomas Sinkunas, Giedrius Gasiunas, Christophe Fremaux, Rodolphe Barrangou, Philippe Horvath and Virginijus Siksnys


Cas3 is an essential protein of unknown function required for CRISPR-based bacteriophage immunity in bacteria. Here, the biochemical activities of Cas3 are demonstrated and mechanistic implications for immunity are discussed

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Publisher: Nature Publishing Group
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Provided by: PubMed Central
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