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From Hen House to Bedside: Tracing Hanafusa’s Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond

By Michael G. Kharas and George Q. Daley

Abstract

The discovery of the Src oncogene was the first step on a long journey toward improved cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and recent advances in oncogene addiction and celebrate Hidesaboro Hanafusa and the many researchers who ushered in the age of target-directed therapy against tyrosine kinase oncoproteins

Topics: Monographs
Publisher: SAGE Publications
OAI identifier: oai:pubmedcentral.nih.gov:3092284
Provided by: PubMed Central
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