Article thumbnail

Endoscopic Ultrasound Fine Needle Aspiration in the Diagnosis of Lymphoma

By Koen Creemers, Olaf van der Heiden, Jan Los, Joost van Esser, David Newhall, Remco S. Djamin and Joachim G. Aerts

Abstract

In recent years, endoscopic ultrasound techniques with Fine Needle Aspiration (FNA) have become an increasingly used diagnostic aid in the differentiation of mediastinal lymphadenopathy. Endobronchial ultrasound (EBUS) and endoesophageal ultrasound (EUS) are now available for clinicians to reach mediastinal and paramediastinal masses using a minimally invasive approach. These techniques are an established component for diagnosing and staging lung cancer and their benefit in the diagnosis of lymphoma's has been highlighted in a number of case studies. However, the lack of tissue architecture obtained by cytological FNA specimens decreases the diagnostic accuracy for benign causes of thoracic lymphadenopathies, lymphomas, and histopathological subtyping of lung cancer. Accordingly, our study group have adapted the FNA sampling technique, resulting in tissue fragments that can be used for histopathological examinations. As an illustration, we report a case of follicular non-Hodgkin lymphoma, diagnosed on tissue fragments obtained by adjusted EUS FNA. We believe that this relatively simple adjustment to routine FNA sampling can help to overcome the diagnostic limitations inherent in cytology obtained by routine FNA

Topics: Case Report
Publisher: Hindawi Publishing Corporation
OAI identifier: oai:pubmedcentral.nih.gov:3087462
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). A .E r n s t ,D .A n a n t h a m ,R .E b e r h a r d t ,M .K r a s n i k ,a n dF
  2. (2010). A .R i b e i r o ,D .P e r e i r a ,M .P .E s c a l ´
  3. (2006). A e rt s,M.D e laha y e ,T .H .v and e rK wast ,B .D a vid
  4. (2010). Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fineneedle
  5. (2010). Endobronchial ultrasound-guided transbronchial needle aspiration for the evaluation of suspected lymphoma,”
  6. (2008). Endoscopic ultrasound-guided fine-needle aspiration and Trucut biopsy in thoracic lesions:
  7. (2010). Endoscopic ultrasound-guided fine-needle aspiration with or without flow cytometry for the diagnosis of primary pancreatic lymphoma—a case series,”
  8. (2005). Esophageal endoscopic ultrasound with fine-needle aspiration with an on-site cytopathologist: high accuracy for the diagnosis of mediastinal lymphadenopathy,” Chest,v o l .
  9. (2008). EUS-FNA of enlarged necrotic lymph nodes may cause infectious mediastinitis,”
  10. (2005). Fine-needle aspiration of a primary mediastinal large B-cell lymphoma: a case report with cytologic, histologic, and flow cytometric considerations,”
  11. (2008). P u l i ,J .B .K .R e d d y ,M .L .B e c h t o l de ta l . ,“ E n d o -scopic ultrasound: it’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review,”
  12. (2009). R i n t o u l ,K .G .T o u r n o y ,H .E lD a l ye ta l .
  13. (2009). Role of endoscopic ultrasound-guided fine-needle aspiration with flow cytometry to diagnose lymphoma:a single center experience,”
  14. (2010). T o u r n o y ,A .B o l l y ,J .G .A e r t se ta l . ,“ T h ev a l u e of endoscopic ultrasound after bronchoscopy to diagnose thoracicsarcoidosis,”European