Article thumbnail

Resolution of Dialyzer Membrane-Associated Thrombocytopenia with Use of Cellulose Triacetate Membrane: A Case Report

By Feyisayo Olafiranye, Win Kyaw and Oladipupo Olafiranye


Blood and dialyzer membrane interaction can cause significant thrombocytopenia through the activation of complement system. The extent of this interaction determines the biocompatibility of the membrane. Although the newer synthetic membranes have been shown to have better biocompatibility profile than the cellulose-based membranes, little is known about the difference in biocompatibility between synthetic membrane and modified cellulose membrane. Herein, we report a case of a patient on hemodialysis who developed dialyzer-membrane-related thrombocytopenia with use of synthetic membrane (F200NR polysulfone). The diagnosis of dialyzer membrane-associated thrombocytopenia was suspected by the trend of platelet count before and after dialysis, and the absence of other possible causes of thrombocytopenia. We observed significant improvement in platelet count when the membrane was changed to modified cellulose membrane (cellulose triacetate). In patients at high risk for thrombocytopenia, the modified cellulose membrane could be a better alternative to the standard synthetic membranes during hemodialysis

Topics: Case Report
Publisher: Hindawi Publishing Corporation
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1987). C h e n o w e t ha n dL .W .H e n d e r s o n ,“ C o m p l e m e n ta c t i v a -tionduringhemodialysis:laboratoryevaluationofhemodialyzers,”
  2. (2002). Cell activation and cellular-cellular interactions during hemodialysis: effect of dialyzer membrane,”
  3. (2010). Cellulose triacetate dialyzer reduces platelet loss during continuous veno-venous hemofiltration,”
  4. (2003). Comparison of the effects of cellulose triacetate and polysulfone membrane on GPIIb/IIIa and platelet activation,”
  5. (1987). Complement activation in extracorporeal circuits,”
  6. (1995). Compositionof polymer membranes fortherapies of end-stage renal disease,”
  7. (1999). i r o l l i ,E .B a l l o n e ,L .A m o r o s oe ta l . ,“ L e u k o c y t ea d h e s i o n moleculesandleukocyte-platelet interactionsduringhemodialysis: effects of different synthetic membranes,”
  8. (2003). Platelet loss across the hemofilter during continuous hemofiltration,”Case Reports in
  9. (1999). Thrombocytopenia,” in Oxford Textbook of