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Mamld1 Knockdown Reduces Testosterone Production and Cyp17a1 Expression in Mouse Leydig Tumor Cells

By Michiko Nakamura, Maki Fukami, Fumihiro Sugawa, Mami Miyado, Katsuya Nonomura and Tsutomu Ogata
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3084764
Provided by: PubMed Central

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Citations

  1. (2006). CXorf6 is a causative gene for hypospadias.
  2. (2008). Mastermindlike domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.
  3. (2003). Mouse Leydig tumor cells produce C-19 steroids, including testosterone.
  4. (2010). Mutational study of the MAMLD1-gene in hypospadias.
  5. (2008). Mutations of CXorf6 are associated with a range of severities of hypospadias.
  6. (2008). Steroidogenic factor-1 (SF-1, Ad4BP, NR5A1) and disorders of testis development.