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Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

By Kuei-Hua Chang, Parminder Singh Multani, Kai-Hui Sun, Fabien Vincent, Yolanda de Pablo, Soumitra Ghosh, Ritika Gupta, Hyun-Pil Lee, Hyoung-gon Lee, Mark A. Smith and Kavita Shah


We show that nuclear fragmentation in neurodegeneration is an early trigger for cell death initiated by deregulated Cdk5. Cdk5 induces nuclear dispersion by direct phosphorylation of lamins in neurons and in vivo Alzheimer's disease (AD) mouse models. Inhibition of nuclear fragmentation rescues neurons from cell death, underscoring the significance of this event in AD

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Publisher: The American Society for Cell Biology
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