Article thumbnail

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

By Céline Baldeyron, Gaston Soria, Danièle Roche, Adam J. L. Cook and Geneviève Almouzni

Abstract

p150CAF-1-mediated recruitment of HP1α to DNA is essential for efficient assembly of DNA damage response complexes and subsequent homologous recombination repair

Topics: Research Articles
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:3082177
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1996). A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
  2. (2006). Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
  3. (2007). Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.
  4. (2003). Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
  5. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
  6. (2009). DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase. Cell Cycle.
  7. (2004). DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.
  8. (2006). Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4.
  9. (2010). Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO
  10. (2007). Human CtIP promotes DNA end resection.
  11. (2005). MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
  12. (2006). New histone incorporation marks sites of UV repair in human cells.
  13. (2007). Positional stability of single double-strand breaks in mammalian cells.
  14. (2005). Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair. Nucleic Acids Res. 33:4928– 4939. doi:10.1093/nar/gki806
  15. (2004). Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.
  16. (1981). The nucleosome.
  17. (2006). XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.
  18. (2009). XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions.