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Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

By Yasuhito Shirai, Shoko Morioka, Megumi Sakuma, Ken-ichi Yoshino, Chihiro Otsuji, Norio Sakai, Kaori Kashiwagi, Kazuhiro Chida, Ryutaro Shirakawa, Hisanori Horiuchi, Chikako Nishigori, Takehiko Ueyama and Naoaki Saito


A small G protein, RalA, was identified as a binding partner of PKCη. The binding led to activation of RalA and actin depolymerization associated with keratinocyte differentiation. These results provide new insight into the molecular mechanism of cytoskeletal regulation that leads to drastic change of cell shape

Topics: Articles
Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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