Article thumbnail

Shift Work in Nurses: Contribution of Phenotypes and Genotypes to Adaptation

By Karen L. Gamble, Alison A. Motsinger-Reif, Akiko Hida, Hugo M. Borsetti, Stein V. Servick, Christopher M. Ciarleglio, Sam Robbins, Jennifer Hicks, Krista Carver, Nalo Hamilton, Nancy Wells, Marshall L. Summar, Douglas G. McMahon and Carl Hirschie Johnson
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2006). A clock shock: mouse CLOCK is not required for circadian oscillator function.
  2. (2006). A compromise phase position for permanent night shift workers: circadian phase after two night shifts with scheduled sleep and light/dark exposure.
  3. (2007). A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
  4. (2003). A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
  5. (2004). A marker for the end of adolescence.
  6. (2006). A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans.
  7. (2007). Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.
  8. (2007). Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities.
  9. (2003). Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.
  10. (2001). An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
  11. (2008). Analysis of gene regulatory networks in the mammalian circadian rhythm.
  12. (2001). Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.
  13. (2005). Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it?
  14. (2007). autistic disorder: support for the clock genes/social timing hypothesis.
  15. (1998). Changes in cortisol secretion during shiftwork: implications for tolerance to shiftwork?
  16. (2006). Chronic jet-lag increases mortality in aged mice.
  17. (2002). Circadian adaptation to night-shift work by judicious light and darkness exposure.
  18. (2009). Circadian timing of REM sleep is coupled to an oscillator within the dorsomedial suprachiasmatic nucleus.
  19. (2010). CLOCK Gene Variants Associate with Sleep Duration in Two Independent Populations. Biol Psychiatry.
  20. (2009). CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.
  21. (2004). Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work.
  22. (2005). Daytime sleepiness, sleep habits and occupational accidents among hospital nurses.
  23. (2004). Determinants of shift-work adjustment for nursing staff: the critical experience of partners.
  24. (2010). Disregulation of inflammatory responses by chronic circadian disruption.
  25. (2009). Disruption of the circadian timing systems: molecular mechanisms in mood disorders.
  26. (2008). Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism.
  27. (2007). Expression of Clock Genes in Human Peripheral Blood Mononuclear Cells throughout the Sleep/Wake and Circadian Cycles. Chronobiology International:
  28. (2008). Genetic differences in human circadian clock genes among worldwide populations.
  29. (2003). Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
  30. (2004). Health and psychosocial effects of flexible working hours. Rev Saude Publica 38 Suppl:
  31. (2003). Health disorders of shift workers.
  32. (2007). How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes.
  33. (2009). Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism.
  34. (2010). Incidence of metabolic syndrome among night-shift healthcare workers.
  35. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
  36. (2001). Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people.
  37. (2003). Life between clocks: daily temporal patterns of human chronotypes.
  38. (2003). Measuring sleep habits without using a diary: the sleep timing questionnaire.
  39. (2009). Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession.
  40. (2010). mouse circadian system revealed by in vitro analysis.
  41. (2008). Night shift performance is improved by a compromise circadian phase position: study 3. Circadian phase after 7 night shifts with an intervening weekend off.
  42. (2003). Night-shift work and risk of colorectal cancer in the nurses’ health study.
  43. (2009). NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
  44. (2011). Nurses’ work schedule characteristics, nurse staffing, and patient mortality.
  45. (2010). Obesity and high blood pressure of 12-hour night shift female clean-room workers.
  46. (2009). PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.
  47. (2007). PER3 polymorphism predicts sleep structure and waking performance.
  48. (2008). Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters.
  49. (2001). Postprandial hormone and metabolic responses amongst shift workers in Antarctica.
  50. (2009). Practical interventions to promote circadian adaptation to permanent night shift work: study 4.
  51. (2008). Prevalence of mental disorders among shift work hospital nurses in Shiraz,
  52. (2004). Quality of life, life satisfaction and happiness in shift- and non-shiftworkers. Rev Saude Publica 38 Suppl:
  53. (1993). Reliability of sleep diaries for assessment of sleep/wake patterns.
  54. (2000). Resetting central and peripheral circadian oscillators in transgenic rats.
  55. (2001). Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study.
  56. (2009). Shift work aggravates metabolic syndrome development among early-middle-aged males with elevated ALT.
  57. (2008). Shift work, hCLOCK T3111C polymorphism, and endometriosis risk.
  58. (1997). Shiftwork Advantages as Predictors of Health.
  59. (2009). Shiftwork impacts and adaptation among health care workers.
  60. (2005). Shiftwork locus of control, situational and behavioural effects on sleepiness and fatigue in shiftworkers.
  61. (1999). Singlestrand conformation polymorphism and heteroduplex analysis for gel-based mutation detection.
  62. (2009). Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes.
  63. (2008). Sleep in America Poll Washington, DC: National Sleep Foundation.
  64. (2006). Social jetlag: misalignment of biological and social time.
  65. (2008). The environmental contribution to gene expression profiles.
  66. (2008). The genetics of mammalian circadian order and disorder: implications for physiology and disease.
  67. (2005). The rhythm of rest and excess.
  68. (2010). The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.
  69. (2003). The ubiquitous nature of epistasis in determining susceptibility to common human diseases.
  70. (2007). Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.
  71. (1997). Twentyfour-hour melatonin and core body temperature rhythms: their adaptation in night workers.
  72. (2007). Working on atypical schedules.