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Macroamylasemia as the First Manifestation of Celiac Disease

By Roman Depsames, Zvi Fireman, Eva Niv and Yael Kopelman


Macroamylasemia is a biochemical disorder characterized by an elevated serum amylase activity resulting from the circulation of a macromolecular complex of amylase with a serum component, often an immunoglobulin. The increased molecular weight of this complex prevents the normal renal excretion of the enzyme. A few cases of celiac patients with macroamylasemia have been published in whom the biochemical disorder disappeared after treatment with a gluten-free diet

Topics: Published: June 2008
Publisher: S. Karger AG
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Provided by: PubMed Central

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