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Kayexalate Intake (in Sorbitol) and Jejunal Diverticulitis, a Causative Role or an Innocent Bystander?

By Marc Pusztaszeri, Michel Christodoulou, Stefania Proietti and Walter Seelentag

Abstract

Small intestine diverticulosis is a rare entity that is asymptomatic in the majority of cases. However, it may cause serious complications, such as infection, hemorrhage, intestinal obstruction and diverticulitis. Kayexalate (sodium polystyrene sulfonate) in sorbitol has been associated with colonic necrosis and less frequently with upper gastrointestinal injuries in a subset of uremic patients treated for hyperkalemia. We report a case of jejunal diverticulosis with mucosal injury and diverticulitis in a uremic patient treated with Kayexalate and discuss the potential role of Kayexalate in the pathogenesis of diverticulitis

Topics: Published: December 2007
Publisher: S. Karger AG
OAI identifier: oai:pubmedcentral.nih.gov:3073802
Provided by: PubMed Central

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Citations

  1. E: Jejunal diverticulosis: a potentially dangerous entity.
  2. GM: Intestinal necrosis due to sodium polystyrene (Kayexalate) in sorbitol enemas: clinical and experimental support for the hypothesis. Surgery
  3. GY: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2003. A 79-year-old man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention.
  4. Hsieh CB: Diverticulosis of the jejunum with intestinal obstruction: A case report.
  5. (1992). Intestinal necrosis associated with postoperative orally administered sodium polystyrene sulfonate in sorbitol.
  6. Pegg SP: Colonic necrosis and perforation following oral sodium polystyrene sulfonate (Resonium A/Kayexalate) in a burn patient.
  7. SC: Acute colonic necrosis associated with sodium polystyrene sulfonate (Kayexalate) enemas in a critically ill patient: case report and review of the literature.
  8. (1983). Schuffler MD: Jejunal diverticulosis. A heterogeneous disorder caused by a variety of abnormalities of smooth muscle or myenteric plexus.
  9. Small bowel diverticulosis: an overlooked entity.
  10. (1997). SR: Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (Kayexalate) in sorbitol: an unrecognized condition.
  11. Stock K: Jejunal diverticulosis.
  12. Taubin HL: Jejunoileal diverticula.
  13. (1998). Tsiftsis D: The clinical significance of acquired jejunoileal diverticula.
  14. TT: Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings.
  15. (1992). Vernava AM 3rd: Clinical implications of jejunoileal diverticular disease. Dis Colon Rectum