Article thumbnail

Genetic Analysis of the Neurosteroid Deoxycorticosterone and Its Relation to Alcohol Phenotypes: Identification of QTLs and Downstream Gene Regulation

By Patrizia Porcu, Todd K. O'Buckley, Soomin C. Song, Jo Lynne Harenza, Lu Lu, Xusheng Wang, Robert W. Williams, Michael F. Miles and A. Leslie Morrow
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2006). A highresolution single nucleotide polymorphism genetic map of the mouse genome.
  2. (2004). A new set of BXD recombinant inbred lines from advanced intercross populations in mice.
  3. (2002). Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task.
  4. (1994). Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BXD recombinant inbred strains.
  5. (1995). Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains.
  6. (2001). Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder.
  7. (2009). Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation
  8. (1996). An 8-year follow-up of 450 sons of alcoholic and control subjects.
  9. (2006). An evaluation of the level of response to alcohol, externalizing symptoms, and depressive symptoms as predictors of alcoholism.
  10. (2007). An informatics approach to systems neurogenetics.
  11. (2009). An overview of genetic influences in alcoholism.
  12. (1989). Anticonvulsant profile of the progesterone metabolite 5a-pregnan-3a-ol-20-one.
  13. (1991). Anxiolytic effects of 3a-hydroxy-5a[b]-pregnan-20-one: Endogenous metabolites of progesterone that are active at the GABAA receptor.
  14. (2002). Behavioral action of ethanol in Porsolt’s forced swim test: modulation by 3a-hydroxy-5a-pregnan-20-one.
  15. (1997). Brain neurosteroids during the mouse oestrous cycle.
  16. (2005). Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function.
  17. (2010). Differential effects of ethanol on serum GABAergic 3a,5a/3a,5b neuroactive steroids in mice, rats, cynomolgus monkeys and humans.
  18. (2008). Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects.
  19. (1984). Effect of ethanol on the hypothalamicpituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF).
  20. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains.
  21. (1981). Estimating genetic correlations from inbred strains.
  22. (2010). Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
  23. (1999). Ethanol markedly increases ‘‘GABAergic’’ neurosteroids in alcohol-preferring rats.
  24. (2004). Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
  25. (2005). Evaluation of GABAergic neuroactive steroid 3a-hydroxy-5a-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats.
  26. (2004). Failure of chydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized-orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals.
  27. (2005). GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride.
  28. (1995). Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.
  29. (2006). Genetic and environmental effects on complex traits in mice.
  30. (1994). Genetic animal models of alcohol and drug abuse.
  31. (1995). Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.
  32. (2009). Genetics of alcohol dependence.
  33. (1989). Genetics of alcoholism.
  34. (2010). Highthroughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.
  35. (2002). HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.
  36. (2006). Hypothalamic-pituitaryadrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior.
  37. (2006). Hypothalamicpituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys.
  38. (2002). Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive.
  39. (1999). Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
  40. (2010). Individual differences in prefrontal cortex function and the transition from drug use to drug dependence.
  41. (2005). Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis.
  42. (1994). Localization of genes affecting alcohol drinking in mice.
  43. (1994). Low level of response to alcohol as a predictor of future alcoholism.
  44. (2007). Mechanisms of neurosteroid interactions with GABA(A) receptors.
  45. (2000). Neuroactive steroid 3a-hydroxy-5a-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
  46. (2003). Neuroactive steroid 3a-hydroxy-5a-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats.
  47. (2009). Neuroactive steroid biomarkers of alcohol sensitivity and alcoholism risk.
  48. (2006). Neuroactive steroids as modulators of depression and anxiety.
  49. (2003). Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties.
  50. (1999). Neurosteroids mediate pharmacological effects of ethanol: A new mechanism of ethanol action?
  51. (2009). Neurosteroids: endogenous allosteric modulators of GABA(A) receptors.
  52. (1991). Non-genomic and genomic effects of steroids on neural activity.
  53. (1996). Permutation tests for multiple loci affecting a quantitative character.
  54. (2006). Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus.
  55. (2008). Progesterone exerts neuroprotective effects after brain injury.
  56. (2007). Progesterone: therapeutic opportunities for neuroprotection and myelin repair.
  57. (2002). Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice.
  58. (1978). Recombinant inbred strains: use in gene mapping.
  59. (2008). Review. Neurogenetic studies of alcohol addiction.
  60. (2002). Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis.
  61. (1992). Steroid metabolism by constitutive cytochromes P450.
  62. (2002). Stress-induced deoxycorticosterone-derived neurosteroids modulate GABAA receptor function and seizure susceptibility.
  63. (1991). Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.
  64. (2005). Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response.
  65. (2011). The genetic basis of adrenal weight in BXD recombinant inbred mice. Mamm Genome;
  66. (2001). The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis.
  67. (2001). The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence.
  68. (2009). The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress,
  69. (2003). The search for genes related to a low-level response to alcohol determined by alcohol challenges.
  70. (2008). The stressed prefrontal cortex.
  71. (1991). Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology.
  72. (2004). WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior.
  73. (2003). WebQTL: web-based complex trait analysis.