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Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors

By Muhammad Raza, Abdullah A. Alghasham, Mohammad S. Alorainy and Tarig M. El-Hadiyah

Abstract

This study investigated antiepileptic effects of the main constituents of Nigella sativa (NS) seed (i.e. aqueous extract (AE), fixed oil (FO), volatile oil (VO)) and the main components of its VO (i.e. thymoquinone, α-pinene and p-cymene) using pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced convulsions. The potential of these constituents to induce minimal neurological deficit (MND) was also evaluated by using chimney test

Topics: Original Articles
Publisher: Qassim University, Kingdom of Saudi Arabia
OAI identifier: oai:pubmedcentral.nih.gov:3068708
Provided by: PubMed Central
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