Article thumbnail

Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

By Crystal Blake, Kimberly M Fabick, Kenneth DR Setchell, Trent D Lund and Edwin D Lephart
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1997). (eds): Estrogens and Antiestrogens.
  2. (2002). A: Obesity, body size, and risk of postmenopausal breast cancer: the Women’s Health Initiative (United States). Cancer Causes and Control
  3. (2010). Activation of transgenic estrogen receptor-beta by selected phytoestrogens in a stably transduced rat serotonergic cell line.
  4. and diet: a possible role of phytoestrogens (isoflavones) in Alzheimer’s disease?
  5. (2010). Anti-anxiety, cognitive, and steroid biosynthetic effects of an isoflavone-based dietary supplement are gonad and sexdependent in rats. Brain Res
  6. (2009). Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet. Nutr Res
  7. (1990). Artigas F: Relationship between serotoninergic measures in blood and cerebrospinal fluid simultaneously obtained in humans.
  8. (2007). BB: Surgical verses natural menopause: cognitive issues. Menopause
  9. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
  10. (2006). CA: A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior. Neuropsychopharm
  11. (2006). CA: Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice.
  12. (2005). Castrogiovanni P: Plasma catecholamine levels after fluoxetine treatment in depressive patients. Neuropsychobiology
  13. (2001). Chapman PF: Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice. PNAS
  14. (2003). Clinical Guide To Nutrition and Dietary Supplements in Disease.
  15. (2005). Conference Statement on management of menopause-related symptoms.
  16. (2002). Cook PS: Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERα): a potential role for estrogen receptor beta (ERβ). Horm Metab Res
  17. (2003). Cook PS: The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology
  18. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature
  19. (2004). DM: Menopause transition: Annual changes in serum hormonal patterns over the menstrual cycle in women during a nineyear period prior to menopause.
  20. (2004). E: Ovarian function following radiation and chemotherapy for cancer.
  21. (1986). Equol and other compounds from bovine urine as monoamine oxidase inhibitors.
  22. (2002). for the WHI Investigators: Risks and Benefits of Estrogen Plus Progestin in healthy Postmenopausal Women: Principal results from the Women’s Health Initiative Randomized Controlled Trial. JAMA
  23. (2005). Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology (Berl)
  24. (2007). Frye CA: Administration of estrogen receptor beta-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats. Pharmacol Biochem Behav
  25. (2008). Frye CA: Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen. Steroids
  26. (1976). GN: Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats.
  27. (1998). Gustafsson JA: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology
  28. (2001). Gustafsson JA: Mechanisms of estrogen action. Physiol Rev
  29. (2005). Heubi JE: S-Equol, a potent ligand for estrogen receptor {beta}, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.
  30. (2003). I: Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice.
  31. (1996). JA: A review of the clinical effects of phytoestrogens. Obstet Gynecol
  32. (2004). JA: Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and Sequols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem
  33. (2006). Korach KS: Estrogen receptors and human disease.
  34. (2001). Lephart ED: Dietary Soy Phytoestrogens Produce Anxiolytic Effects in The Elevated Plus-Maze. Brain Res
  35. (2001). Lephart ED: Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens.
  36. (2010). Liposits Z: Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat. Endocrinology
  37. (2004). Lowik CW: The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis. J Bone Miner Res
  38. (2003). Menopausal transition and increased depressive symptomatology: a community based prospective study. Maturitas
  39. (2005). Mouse behavioural analysis in systems biology.
  40. (2009). Nef S: Soy, phytoestrogens and metabolism: A review. Mol Cell Endocrinol
  41. (2010). Ogle WO: Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol
  42. (2009). Oktay K: Fertility Preservation for Breast Cancer Patients. Sem Reprod Med
  43. (2007). Onur E: Effects of postmenopausal hormone replacement therapy on body fat composition. Gynecological Endocrinology
  44. Organization: Research on the Menopause in the 90 s.
  45. (1997). Phyto-oestrogens and Western diseases. Ann Med
  46. (2007). Platelet serotonin levels support depression scores for women with postpartum depression.
  47. (2010). Prenatal Exposure to Equol Decreases Body Weight and Depressive-Like Behaviors In Male and Female Offspring. Curr Topics Nutr Res
  48. (1997). Reduced whole blood serotonin in major depression. Depress Anxiety
  49. (2006). Regulatory Behavior and Skin Temperature in MidAged Male Rats on Three Different Isoflavone-Containing Diets. J Med Food
  50. (2005). RJ: Novel actions of estrogen receptor-β on anxiety-related behaviors. Endocrinology
  51. (2009). RS: Advances in the treatment of menopausal symptoms. Women’s Health
  52. (2002). Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients.
  53. (2004). TD: Behavioral Effects of Endocrine-distrupting Substances:
  54. (2000). The menopause transition and the aging process: A population perspective. Aging Clin Exp Res
  55. (2009). The NSABP Study of Tamoxifen and Raloxifene (STAR) trial. Expert Rev Anticancer Ther
  56. (2008). VC: Selective estrogen receptor modulators and phytoestrogens. Planta Med
  57. (2003). WL: Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta.
  58. (2004). WR: Dietary isoflavones alter regulatory behaviors, metabolic hormones and neuroendocrine function in Long-Evans male rats. Metab Nutr